| Project/Area Number |
20791375
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
IDE Yoshiaki The Nippon Dental University, 生命歯学部, 助教 (70409225)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 放射線治療 / 歯根形成 / 再生医療 / 小児白血病 / マイクロCT / BrdU / PCNA / ヘルトヴィッヒ上皮鞘 / 副作用 / 上皮間葉相互作用 / 放射線障害 / マウス / 臼歯 |
|---|
| Research Abstract |
The purpose of this study was to elucidate the mechanisms of tooth root formation disturbance caused by radiation. We found that in the tooth root of a mouse, the root furcation is formed 11 days after birth, and that the tooth root is completed 21 days after birth. The tooth root formation disturbance was examined according to different doses of radiation through three-dimensional observation by micro CT. The tooth root formation disturbance is observed with 5Gy of radiation, and that at 10Gy, only 1/2-2/3 the size of non-irradiated (0Gy) tooth root was formed. Hertwig's epithelial root sheath (HERS) is considered to play an important role in tooth root formation, and we are investigating this area using a cell proliferation marker.
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