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The analysis of innate immunity system in the pathogenesis of pulpitis.

Research Project

Project/Area Number 20791386
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionThe University of Tokushima

Principal Investigator

TAKAHASHI Kanako  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (80403715)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords歯髄炎 / 自然免疫 / 細菌性因子 / 抗菌因子
Research Abstract

Pulpitis is an infectious disease followed.dental caries, and it finally leads to dental pulp necrosis. The aim of this study was to analyze the effect of caries-related bacterium or bacterial component on dental pulp. Especially, it was focused on alarmin, molecule led to inflammation, and investigated the production and release of alarmin from dental pulp stimulated with caries-related bacterium. Consequently, the production and release of alarmin ware observed in pulpitis, and these results indicated that alarmin may be involved in the progression of pulpitis.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (20 results)

All 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (16 results)

  • [Journal Article] Roles of TLR2, TLR4, NOD2 and NOD1 in pulp fibroblasts2009

    • Author(s)
      Hirao K, Yumoto H, Takahashi K, Mukai K, Nakanashi T, Matsuo T
    • Journal Title

      J Dent Res 88(8)

      Pages: 762-767

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of TLR2, TLR4, NOD2 and NOD1 in pulp fibroblasts2009

    • Author(s)
      HIRAO KOJI, et al
    • Journal Title

      Journal of Dental Research 88

      Pages: 762-767

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines2008

    • Author(s)
      Takahashi K, Nakanishi T, Yumoto H, Adachi T, Matsuo T
    • Journal Title

      Oral Microbial Immunol 23(4)

      Pages: 320-32

    • NAID

      120005823503

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] CCL20 production is induced in human dental pulp upon stimulation by Streptococcus mutans and proinflammatory cytokines2008

    • Author(s)
      KANAKO TAKAHASHI, et.al.
    • Journal Title

      Oral Microbiology Immunology 23

      Pages: 320-327

    • NAID

      120005823503

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口腔病原菌に対する高周波・電磁波照射-の殺菌効果2010

    • Author(s)
      湯本浩通, 他
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Final Research Report
  • [Presentation] 培養歯髄細胞におけるAlarminの産生・放出機構の解析2010

    • Author(s)
      高橋加奈子, 他
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 口腔病原菌に対する高周波・電磁波照射の殺菌効果2010

    • Author(s)
      湯本浩通, 他
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] TLRリガンド刺激したヒト培養歯髄細胞におけるIL-6, CXCL10産生をインターフェロンγは増強させる2009

    • Author(s)
      武川大輔, 他
    • Organizer
      第131回日本歯科保存学会秋季学術大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 炎症性サイトカインやPAMP刺激によるヒト培養歯髄細胞におけるAlarminの産生・放出2009

    • Author(s)
      高橋加奈子, 他
    • Organizer
      第131回日本歯科保存学会秋季学術大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2009-10-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 炎症性サイトカインやPAMP刺激によるヒト培養歯髄細胞におけるAlamlinの産生・放出2009

    • Author(s)
      高橋加奈子, 他
    • Organizer
      第131回日本歯科保存学会秋季学術大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト歯-髄細胞における炎症関連因子発現に対するカテキンの影響2009

    • Author(s)
      中西正, 他
    • Organizer
      第130回日本歯科保存学会春季学術大会
    • Year and Date
      2009-06-11
    • Related Report
      2009 Final Research Report
  • [Presentation] ヒト歯髄細胞における炎症関連因子発現に対するカテキンの影響2009

    • Author(s)
      中西正, 他
    • Organizer
      第130回日本歯科保存学会春季学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] カテキンの培養歯髄細胞における抗炎症効果に関与するシグナル伝達機構の解析2009

    • Author(s)
      湯本浩通, 他
    • Organizer
      第7回日韓合同歯内療法学会
    • Place of Presentation
      都市センターホテル(東京)
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] カテキーンによるTLRやNOD ligands刺激培養歯髄細胞における炎症性メディエーター産生抑制機構2009

    • Author(s)
      湯本浩通, 他
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-03-13
    • Related Report
      2009 Final Research Report
  • [Presentation] カテキンによるTLRやNOD ligands刺激培養歯髄細胞における炎症性メディエーター産生抑制機構2009

    • Author(s)
      湯本浩通, 他
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-03-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 培養歯髄細胞におけるカテキンのcell signalingに対する影響2008

    • Author(s)
      平尾功治, 他
    • Organizer
      第129回日本歯科保存学会秋季学術大会
    • Place of Presentation
      富山国際会議場
    • Year and Date
      2008-11-06
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Functional analysis of pattern recognition receptors expression in pulpal cells2008

    • Author(s)
      KOJI HIRAO, et, al
    • Organizer
      86th General Session & Exhibition of the IADR
    • Place of Presentation
      Metro Toronto
    • Year and Date
      2008-07-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of catechins on cytokine production in human odontblast様ike cells2008

    • Author(s)
      KAYO MUKAI, et, al
    • Organizer
      86th General Session & Exhibition of the IADR
    • Place of Presentation
      Metro Toronto Convention Centre
    • Year and Date
      2008-07-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Functional analysis of pattern recognition receptors expression in pulpal cells2008

    • Author(s)
      KOJI HIRAO, et.al.
    • Organizer
      86^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      Metro Toronto Convention Centre
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of catechins on cytokine production in human odontblast-like cells2008

    • Author(s)
      KAYO MUKAI, et.al.
    • Organizer
      86^<th> General Session & Exhibition of the IADR
    • Place of Presentation
      Metro Toronto Convention Centre
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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