Identification of genes related to the regeneration of human periodontalligament tissue
| Project/Area Number |
20791387
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
SHINSUKE Fujii Kyushu University, 歯内治療科, 助教 (60452786)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ヒト / 歯根膜 / 再生 |
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| Research Abstract |
In this study, the purpose is to identify the genes that is related to the regeneration of human periodontal ligament tissue. In my laboratory, two undifferentiated PDL stem cell lines had been established, and had been named as cell line 1-11 or cell line 1-17. I identified 2420 genes of which expression level was different between these two cell lines. Of them, Transforming growth factor-β1(TGF- β1) was cultured with line 1-11. TGF-β1 suppressed the proliferation of line 1-11 and promoted the gene expression of type I collagen, fibrillin-1 and alpha smooth muscle actin in line 1-11.
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Report
(3 results)
Research Products
(13 results)
