| Project/Area Number |
20791391
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
KOIKE Toshiyuki Health Sciences University of Hokkaido, 歯学部 (10458135)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 直接覆髄 / フォスフォフォリン / コラーゲン / 修復象牙質 / 水酸化カルシウム製剤 / 象牙細管 / 石灰化 / 生体親和性 / 歯学 / Phosphophoryn / Collagen / 再生 |
|---|
| Research Abstract |
Phosphophoryn is an important protein in dentin mineralization. It was extracted from pig teeth, and was combined with type 1 collagen as a trial material. This trial material was placed onto the exposed pulp in maxillary first molar of 8 week-old Wistar rats. Rats were sacrificed 1-3 weeks after operation, and teeth were stained with hematoxylin-eosin. In evaluation of reparative dentin formation and pulp inflammation, the stained sections were compared with calcium hydroxide, a common material. The phosphophoryn-collagen complex induced good reparative dentin, and dental pulp inflammation was mild. Therefore, this material was suggested to have a potential as an alternative material of calcium hydroxide.
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