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A Study of Dentin Regeneration via Mouse Embryonic Stem Cells

Research Project

Project/Area Number 20791406
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

OZEKI Nobuaki  Aichi Gakuin University, 歯学部, 助教 (70469005)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords歯内療法学 / 移植・再生医療 / ES細胞 / 移植・再年医療
Research Abstract

We have examined the mechanism of mouse embryonic stem cells differentiation to odontoblasts for the purpose of dentin regeneration. Morphological analysis indicated that retinoic acid (RA) and bone morphogenetic protein-4 (BMP-4) induced differentiation to the odontogenic pathway. Differentiated cells showed DSPP and DSP ; both markers of odontoblast differentiation. Moreover, we found significant integrin α2β1, α6β1 and αVβ1 expression with increased adhesion and motility on laminin-1 and collagen type-I substrates. These interactions with the extracellular matrix (ECM) are indicative of dental pulp wound healing.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (2 results)

All 2008

All Presentation (2 results)

  • [Presentation] マウスES細胞の象牙質分化能2008

    • Author(s)
      尾関伸明
    • Organizer
      第128回日本歯科保存学会春季学術大会
    • Place of Presentation
      新潟・朱鷺メッセ
    • Year and Date
      2008-06-05
    • Related Report
      2009 Final Research Report
  • [Presentation] マウスES細胞の象牙質分化能2008

    • Author(s)
      尾関伸明
    • Organizer
      2008年日本歯科保存学会春季学術大会
    • Place of Presentation
      新潟朱鷺メッセ
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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