Bone regeneration using the Intelligent artificial bone

• Project/Area Number: 20791428
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: DOI Kazuya Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (80444686)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 骨再生 / 人工骨 / 多孔性ハイドロキシアパタイト / ポリリン酸

Research Abstract

The purpose of this study is to evaluate the combined effect of bFGF and poly(P) on bioactivities of osteoblasts and initial bone regeneration in vitro and in vivo. This study indicated that co-application of bFGF and poly(P) may provide enhanced bone formation by modulating cell proliferation and the mineralization process. It is anticipated that a combined application of bFGF and poly(P) can provide a novel method for bone regeneration in clinical use.

Research Products

• [Journal Article] Enhanced initial bone regeneration with inorganic polyphosphate-adsorbed hydroxyapatite (2010)
  • Author(s): Yuan Q
  • Journal Title: Acta Biomaterialia (In press)
  • Peer Reviewed
• [Journal Article] Enhanced initial bone regeneration with inorganic polyphosphate-adsorbed hydroxyapatite (2010)
  • Author(s): K.Morita
  • Journal Title: Acta Biomaterialia (In press)
  • Peer Reviewed
• [Journal Article] Effect of combined application of bFGF and inorganic polyphosphate on bioactivities of osteoblasts and initial bone regeneration (2009)
  • Author(s): Yuan Q, Kubo T, Doi K, Morita K, Takeshita R, Katoh S, Shiba T, Gong P, Akagawa Y
  • Journal Title: Acta Biomater 5 Pages: 1716-1724
  • Peer Reviewed
• [Journal Article] Effect of combined application of bFGF and inorganic polyphosphate on bioactivities of osteoblasts and initial bone regeneration (2009)
  • Author(s): Q. Yuan
  • Journal Title: Acta Biomaterialia (In press)
  • Peer Reviewed
• [Presentation] Development of inorganic polyphosphate-adsorbed interconnected porous calcium hydroxyapatite as a new bone regeneration material (2009)
  • Author(s): Doi K, et al
  • Organizer: The 13th Meeting of the International College of Prosthodontists
  • Place of Presentation: Cape town, SA
  • Year and Date: 2009-09-10
• [Presentation] Development of inorganic polyphosphate-adsorbed interconnected porous calcium hydroxyapatite as a new bone regeneration material (2009)
  • Author(s): Kazuya Doi
  • Organizer: The 13th Meeting of the International College of Prosthodontists
  • Place of Presentation: ケープタウン(南アフリカ)
  • Year and Date: 2009-09-10
• [Presentation] Bone regeneration ability of newly developed polyphosphate-coated interporous hydroxyapatite (2008)
  • Author(s): K. Morita
  • Organizer: 国際歯科補綴学会
  • Place of Presentation: 名古屋国際会議場(愛知)
  • Year and Date: 2008-06-07