CAN THE SUPPRESSION OF BONE RESORPTION AT EXTRACTION SOCKET STIMULATE OSSEOINTEGRATION?

• Project/Area Number: 20791431
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Kyushu University
• Principal Investigator: OGINO Yoichiro Kyushu University, 大学病院, 助教 (50380431)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 再生医学 / 細胞・組織 / 歯学 / 動物

Research Abstract

The purpose of the present study was to evaluate the relationship between the suppression of bone resorption around the implant bone and osseointegration. As a bone resorption inhibitory factor, Interleukin- 1 receptor antibody (IL-1RA) inhibited the formation of osteoclast like cells in a dose-dependent manner in vitro. In the animal study, IL-1RA stimulated the peri-implant bone formation and cortical bone thickness.