Efficacy of polysaccharide polymers as sustained-release carrier

• Project/Area Number: 20791455
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: KAWAMOTO Akiyo Osaka Dental University, 歯学科, 助教 (50368156)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 歯科補綴学一般 / ヒアルロン酸 / 骨芽細胞 / 高分子多糖 / 骨粗鬆症

Research Abstract

The purpose of this study was to examine the efficacy of polysaccharide polymers as a sustained-release carrier for recovery and regeneration of periodontal tissue in vitro. Osteoblast-like cells were cultured with hyaluronan for examining the osteoblast activity, cell attachment, proliferation and migration with or without anti-CD44mAb. Effect of HA on osteoblast activity, cell attachment and proliferation was related to CD44 but cell migration was not.

Research Products

• [Journal Article] Effect of combined use of daidzein and raloxifene on osteoblast-like cells. (2009)
  • Author(s): M Nomura, A Kawamoto, Y Komasa.
  • Journal Title: J Osaka Dent Univ. 43(2) Pages: 135-141
  • NAID: 110007386255
• [Journal Article] Effect of combined use of daidzein and raloxifene on osteoblast-like cells (2009)
  • Author(s): M.Nomura
  • Journal Title: J Osaka Dent Univ 43 Pages: 135-141
  • Peer Reviewed
• [Journal Article] Influence of adipocytokines on differentiation of pro-osteoblastic cells. (2008)
  • Author(s): A Kamada, T Ikeo, Y Yoshikawa, E Domae, S Goda, I Tamura, H Kon-I, J Okazaki, A Kawamoto, Y Komasa, I Toda, F Suwa.
  • Journal Title: J Oral Tissue Engin. 6(1) Pages: 17-23
  • NAID: 110007004835
• [Journal Article] Influence of Adipocytokines on Differentiation of Pro-osteoblastic Cells (2008)
  • Author(s): A. Kamada
  • Journal Title: J Oral Tissue Engin 6 Pages: 17-23
  • Peer Reviewed
• [Presentation] Heparan sulfate proteoglycans modulate osteogenic differentiation through heparan sulfate chains. (2009)
  • Author(s): A Kamada, T Ikeo, Y Yoshikawa, E Domae, S Goda, I Tamura, A Kawamoto, J Okazaki, Y Komasa, Y Takaishi, T Miki, T Fujita.
  • Organizer: The 30th Annual Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Montreal
  • Year and Date: 2009-09-15
• [Presentation] Various roles of syndecan family in osteoblastic cells. (2009)
  • Author(s): T Ikeo, A Kamada, Y Yoshikawa, E Domae, S Goda, I Tamura, A Kawamoto, J Okazaki, Y Komasa, Y Takaishi, T Miki, T Fujita.
  • Organizer: The 30th Annual Meeting of the American Society for Bone and Mineral Research.
  • Place of Presentation: Montreal
  • Year and Date: 2009-09-13
• [Presentation] 骨粗鬆症治療薬と大豆イソフラボンの併用が骨芽細胞の分化に及ぼす影響 (2009)
  • Author(s): 川本章代、野村昌代、吉川美弘、鎌田愛子、池尾隆、岡崎定司、浅井加雄、小正裕
  • Organizer: 第118回日本補綴歯科学会学術大会
  • Place of Presentation: 京都市
  • Year and Date: 2009-06-06
• [Presentation] 骨粗鬆症治療薬と大豆イソフラボンの併用が骨芽細胞の分化に及ぼす影響 (2009)
  • Author(s): 川本章代
  • Organizer: 第118回日本補綴歯科学会学術大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-06-06
• [Presentation] Effect of daidzein together with raloxifene in osteoblast-like cells. (2008)
  • Author(s): M Nomura, A Kawamoto, Y Komasa.
  • Organizer: The 56th Annual Meeting of Japanese Association for Dentla Research.
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-11-30
• [Presentation] Effect of daidzein together with raloxifene in osteoblast-like cells (2008)
  • Author(s): M. Nomura
  • Organizer: 国際歯科研究学会日本部会
  • Place of Presentation: 名古屋市愛知学院大学歯学部楠元学舎
  • Year and Date: 2008-11-30
• [Presentation] Adipocytokine influences differentiation of osteoblasts. (2008)
  • Author(s): A Kamada, T Ikeo, Y Yoshikawa, E Domae, S Goda, I Tamura, A Kawamoto, J Okazaki, Y Komasa, I Toda, F Suwa.
  • Organizer: The 4th Sino-Japanese Conference on Stomatology 2008.
  • Place of Presentation: 西安
  • Year and Date: 2008-09-29
• [Presentation] Development of the efficient turbine grip. (2008)
  • Author(s): A Kawamoto, Y Yoshikawa, A Takeyama, Y Umeyama, N Katayama, A Kamada, J Okazaki, T Ikeo, Y Komasa.
  • Organizer: 86th General Session & Exhibition of the IADR
  • Place of Presentation: Toronto
  • Year and Date: 2008-07-05
• [Presentation] Development of the efficient turbine grip (2008)
  • Author(s): A. KAWAMOTO
  • Organizer: 86th General Session & Exhibition of the International Association for Dental Research
  • Place of Presentation: The Metro Toronto Convention Center
  • Year and Date: 2008-07-05
• [Presentation] ポリマーを介したハイドロキシアパタイト固定化チタンインプラントのラット下顎前歯抜歯窩への埋入 (2008)
  • Author(s): 岡崎定司、松村和明、玄丞烋、坂井大吾、野村昌代、川本章代、柿本和俊、小正裕
  • Organizer: 第51回日本歯科理工学会学術講演会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-04-27