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Developing dental titanium alloys with antibacterial property andbiocompatibility

Research Project

Project/Area Number 20791458
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTohoku University

Principal Investigator

TAKAHASHI Masatoshi  Tohoku University, 大学院・歯学研究科, 助教 (50400255)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsチタン合金 / 歯科用合金 / 抗菌性 / 生体適合性 / 耐食性 / 歯科修復物 / 歯科補綴物 / チタン銀合金
Research Abstract

Aiming to develop dental titanium alloys with antibacterial property and biocompatibility, we prepared experimental Ti-Ag alloys and investigated their properties. The Ti-Ag alloys inhibited biofilm formation, but did not have bactericidal activity. Calcium phosphates were spontaneously formed on the Ti-Ag alloys in a simulated body fluid. The Ti-Ag alloys had excellent corrosion resistance similar to that of titanium. It was suggested that the Ti-Ag alloys were a new type of biomaterial which inhibited biofilm formation without affecting normal microbial flora.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (35 results)

All 2010 2009 2008

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (21 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 歯科用Ti-Zr二元合金の研削性2010

    • Author(s)
      高橋正敏、菊地聖史、奥野攻
    • Journal Title

      日本金属学会誌 74巻(印刷中)

    • NAID

      10026402951

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Corrosion resistance of dental Ti-Ag alloys in NaCl solution2010

    • Author(s)
      Takahashi M、Kikuchi M、Takada Y、Okuno O
    • Journal Title

      Materials Transactions Vol.51

      Pages: 762-766

    • NAID

      10026266940

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Corrosion resistance of dental Ti-Ag alloys in NaCl solution2010

    • Author(s)
      高橋正敏
    • Journal Title

      Materials Transactions 51

      Pages: 762-766

    • NAID

      10026266940

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the retentive force of a β-type Ti-6Mo-4Sn alloy wire clasp2010

    • Author(s)
      Nobuhiro YODA, Masayoshi YOKOYAMA, Genki ADACHI, Masatoshi TAKAHASHI, Keiichi SASAKI
    • Journal Title

      International Journal of Prosthodontics 23

      Pages: 38-41

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯科用Ti-Zr二元合金の研削性2010

    • Author(s)
      高橋正敏
    • Journal Title

      日本金属学会誌 74(印刷中)

    • NAID

      10026402951

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grindability of dental cast Ti-Zr alloys2009

    • Author(s)
      Takahashi M、Kikuchi M、Okuno O
    • Journal Title

      Materials Transactions Vol.50

      Pages: 859-863

    • NAID

      10024813764

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium phosphate formation on Ti-Ag alloys in simulated body fluid2009

    • Author(s)
      Takahashi M、Kikuchi M、Hatori K、Orii Y、Sasaki K、Takada Y
    • Journal Title

      Journal of Biomechanical Science and Engineering Vol.4

      Pages: 318-325

    • NAID

      130000129003

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium phosphate formation on Ti-Ag alloys in simulated body fluid2009

    • Author(s)
      高橋正敏
    • Journal Title

      Journal of Biomechanical Science and Engineering 4

      Pages: 318-325

    • NAID

      130000129003

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grindability of dental cast Ti-Zr alloys2009

    • Author(s)
      高橋正敏
    • Journal Title

      Materials Transactions 50

      Pages: 859-863

    • NAID

      10024813764

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grindability of dental cast Ti-Zr alloys2009

    • Author(s)
      Masatoshi TAKAHASHI
    • Journal Title

      Materials Transactions 50(印刷中)

    • NAID

      10024813764

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium phosphate formation on Ti-Ag alloys in simulated body fluid2009

    • Author(s)
      Masatoshi TAKAHASHI
    • Journal Title

      Journal of Biomechanical Science and Engineering 4(印刷中)

    • NAID

      130000129003

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Ti-Ag合金のISO規格によるアノード分極挙動2010

    • Author(s)
      高橋正敏
    • Organizer
      歯科チタン学会
    • Place of Presentation
      東京都文京区
    • Year and Date
      2010-02-13
    • Related Report
      2009 Final Research Report
  • [Presentation] Ti-Ag合金のISO規格によるアノード分極挙動2010

    • Author(s)
      高橋正敏
    • Organizer
      歯科チタン学会
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2010-02-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spontaneous formation of calcium phosphate on experimental Ti-Ag alloys in simulated body fluid2009

    • Author(s)
      Takahashi M
    • Organizer
      Processing and Fabrication of Advanced Materials
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2009-12-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Spontaneous formation of calcium phosphate on experimental Ti-Ag alloys in simulated body fluid2009

    • Author(s)
      高橋正敏
    • Organizer
      Processing and Fabrication of Advanced Materials
    • Place of Presentation
      Tohoku University(仙台)
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 擬似体液中における試作Ti-Ag合金表面へのリン酸カルシウム自然形成2009

    • Author(s)
      高橋正敏
    • Organizer
      日本歯科理工学会
    • Place of Presentation
      鹿児島県鹿児島市
    • Year and Date
      2009-10-01
    • Related Report
      2009 Final Research Report
  • [Presentation] 擬似体液中における試作Ti-Ag合金表面へのリン酸カルシウム自然形成2009

    • Author(s)
      高橋正敏
    • Organizer
      日本歯科理工学会
    • Place of Presentation
      かごしま県民交流センター(鹿児島)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 擬似体液中におけるTi-Ag合金表面へのリン酸カルシウム形成2009

    • Author(s)
      高橋正敏
    • Organizer
      歯科基礎医学会学術大会
    • Place of Presentation
      新潟県新潟市
    • Year and Date
      2009-09-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 擬似体液中におけるTi-Ag合金表面へのリン酸カルシウム形成2009

    • Author(s)
      高橋正敏
    • Organizer
      歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ti-Ag合金の口腔内細菌付着抑制作用2009

    • Author(s)
      高橋正敏
    • Organizer
      日本歯科理工学会北海道東北支部夏期セミナー
    • Place of Presentation
      福島県郡山市
    • Year and Date
      2009-07-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Ti-Ag合金の口腔内細菌付着抑制作用2009

    • Author(s)
      高橋正敏
    • Organizer
      日本歯科理工学会 北海道東北支部夏期セミナー
    • Place of Presentation
      ビッグアイ(郡山)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Corrosion behavior of Ti-Ag alloys used in dentistry in lactic acid solution2009

    • Author(s)
      Takahashi M
    • Organizer
      The 3rd International Conference on Processing, Manufacturing of Advanced Materials
    • Place of Presentation
      Busan Korea
    • Year and Date
      2009-07-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Corrosion behavior of Ti-Ag alloys used in dentistry in lactic acid solution2009

    • Author(s)
      高橋正敏
    • Organizer
      The 3rd International Conference on Processing, Manufacturing of Advanced Materials
    • Place of Presentation
      Seacloud Hotel(韓国)
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Ti-Ag合金のバイオフィルム形成抑制作用2009

    • Author(s)
      高橋正敏
    • Organizer
      日本歯科理工学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2009-04-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 試作Ti-Ag合金はバイオフィルム形成を抑制する2009

    • Author(s)
      高橋正敏
    • Organizer
      東北大学歯学会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2009-02-27
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 歯科用Ti-Ag合金の機械的性質2009

    • Author(s)
      高橋正敏
    • Organizer
      歯科チタン学会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2009-02-14
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Experimental Ti-Ag alloys inhibit biofilm formation2009

    • Author(s)
      Takahashi M
    • Organizer
      The 3rd International Symposium for Interface Oral Health Science
    • Place of Presentation
      宮城県仙台市
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 歯科CAD/CAM用Ti-Ag合金の機械的性質2008

    • Author(s)
      高橋正敏
    • Organizer
      日本歯科理工学会
    • Place of Presentation
      大阪府豊中市
    • Year and Date
      2008-09-20
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] パルス法による試作チタン合金の弾性率測定2008

    • Author(s)
      高橋正敏
    • Organizer
      日本歯科理工学会北海道東北支部夏期セミナー
    • Place of Presentation
      北海道千歳市
    • Year and Date
      2008-08-23
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 制菌性と生体適合性を兼ね備えた新しい歯科用チタン合金の開発2008

    • Author(s)
      高橋正敏
    • Organizer
      東北大学若手研究者萌芽研究育成プログラム研究成果発表会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2008-07-16
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Ti-Ag合金の乳酸水溶液中における自然電極電位とイオン溶出2008

    • Author(s)
      高橋正敏
    • Organizer
      日本歯科理工学会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2008-04-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Ti-Ag合金のバイオフィルム形成抑制作用2008

    • Author(s)
      高橋正敏
    • Organizer
      日本歯科理工学会
    • Place of Presentation
      東京都江戸川区
    • Year and Date
      2008-04-11
    • Related Report
      2009 Final Research Report
  • [Book] Interface Oral Health Science 20092010

    • Author(s)
      Takahashi M, 他
    • Publisher
      Spriger
    • Related Report
      2009 Final Research Report
  • [Book] Interface Oral Health Science 20092010

    • Author(s)
      Masatoshi TAKAHASHI
    • Publisher
      Spriger(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] バイオフィルム抑制型抗菌性チタン合金2008

    • Inventor(s)
      高橋正敏
    • Industrial Property Rights Holder
      高橋正敏
    • Industrial Property Number
      2008-294012
    • Filing Date
      2008-11-18
    • Related Report
      2009 Final Research Report 2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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