Analysis of periodontal matrix proteins
| Project/Area Number |
20791479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
IWATA Takanori Tokyo Women's Medical University, 医学部, 講師 (60431946)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 再生歯学 / 歯周組織 / 再生医療 / 遺伝子発現 / ヒト歯根膜細胞 / プロテオーム解析 |
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| Research Abstract |
Periodontal tissue, consisting of periodontal ligament, cementum, and alveolar bone, contains cells with stem cell-like properties. In this study, we extracted and transplanted autologous periodontal ligament cells in a canine model, and the advantage of this cytotherapy was revealed. Furthermore, considering an appropriate environment for periodontal ligament cells, we analyzed the matrix proteins expressed by human periodontal ligament cells. Periodontal specific genes were proposed, and expression of some proteins was confirmed by immunohistochemical studies.
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Report
(3 results)
Research Products
(22 results)
