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Analysis of periodontal matrix proteins

Research Project

Project/Area Number 20791479
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTokyo Women's Medical University

Principal Investigator

IWATA Takanori  Tokyo Women's Medical University, 医学部, 講師 (60431946)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords再生歯学 / 歯周組織 / 再生医療 / 遺伝子発現 / ヒト歯根膜細胞 / プロテオーム解析
Research Abstract

Periodontal tissue, consisting of periodontal ligament, cementum, and alveolar bone, contains cells with stem cell-like properties. In this study, we extracted and transplanted autologous periodontal ligament cells in a canine model, and the advantage of this cytotherapy was revealed. Furthermore, considering an appropriate environment for periodontal ligament cells, we analyzed the matrix proteins expressed by human periodontal ligament cells. Periodontal specific genes were proposed, and expression of some proteins was confirmed by immunohistochemical studies.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 9 results) Presentation (9 results) Remarks (2 results)

  • [Journal Article] Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts.2010

    • Author(s)
      Sato T, Abe T, Chida D, Nakamoto N, Hori N, Kokabu S, Sakata Y, Tomaru Y, Iwata T, 他3名、9番目
    • Journal Title

      FEBS Lett. 584巻

      Pages: 817-24

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts.2010

    • Author(s)
      Sato T
    • Journal Title

      FEBS Letters 584

      Pages: 817-24

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell sheet engineering and other novel cell-based approaches to periodontal regeneration.2009

    • Author(s)
      Ishikawa I, Iwata T, 他5名、2番目
    • Journal Title

      Periodontol 2000 51巻

      Pages: 220-238

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model.2009

    • Author(s)
      Iwata T, 他7名、1番目
    • Journal Title

      Biomaterials. 30巻

      Pages: 2716-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model.2009

    • Author(s)
      Iwata T
    • Journal Title

      Biomaterials 30

      Pages: 2716-23

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell sheet engineering and other novel cell-based approaches to periodontal regeneration.2009

    • Author(s)
      Ishikawa I
    • Journal Title

      Periodontology 2000 51

      Pages: 220-38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model2009

    • Author(s)
      Iwata, et.al.
    • Journal Title

      Biomaterials 30(In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞シート技術を用いた歯周組織再生2008

    • Author(s)
      岩田隆紀, 他2名、1番目
    • Journal Title

      バイオマテリアル-生体材料- 26巻

      Pages: 194-198

    • NAID

      10021140805

    • Related Report
      2009 Final Research Report
  • [Journal Article] Porcine dentin sialophosphoprotein: length polymorphisms, glycosylation, phosphorylation, and stability.2008

    • Author(s)
      Yamakoshi Y, Lu Y, Hu JC, Kim JW, Iwata T, 他6名、5番目
    • Journal Title

      J Biol Chem. 283巻

      Pages: 14835-44

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Porcine dentin sialophosphoprotein : length polymorphisms, glycosylation, phosphorylation, and stability.2008

    • Author(s)
      Yamakoshi, et.al.
    • Journal Title

      Journal of biological chemistry 283

      Pages: 14835-14844

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞シート技術を用いた歯周組織再生2008

    • Author(s)
      岩田隆紀、矢代麗子、石川烈
    • Journal Title

      バイオマテリアル-生体材料- 26

      Pages: 194-198

    • NAID

      10021140805

    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞シートによる歯周組織の再生-ヒト臨床応用に向けた取組み-2010

    • Author(s)
      岩田隆紀, 他
    • Organizer
      第9回日本再生医療学会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Periodontal regeneration with multi-layered periodontal ligament cell sheets2009

    • Author(s)
      Iwata T, 他
    • Organizer
      IADR 87th General Session and Exhibition
    • Place of Presentation
      マイアミ(米国)
    • Year and Date
      2009-04-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Periodontal regeneration with multi-layered periodontal ligament cell sheets2009

    • Author(s)
      Iwata T
    • Organizer
      IADR 87^<th> General Session and Exhibition
    • Place of Presentation
      米国・マイアミ
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞シート工学を用いた歯周組織の再生2009

    • Author(s)
      岩田隆紀, 他
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-05
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞シート工学を用いた歯周組織の再生2009

    • Author(s)
      岩田隆紀, 他
    • Organizer
      第8回日本再生医療学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2009-03-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 歯根膜シートを用いた歯周組織再生療法2008

    • Author(s)
      秋月達也, 他
    • Organizer
      第21回日本歯科医学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞シート工学を用いた歯周組織の再生2008

    • Author(s)
      岩田隆紀, 他
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2009 Final Research Report
  • [Presentation] 細胞シート工学を用いた歯周組織の再生2008

    • Author(s)
      岩田隆紀, 他
    • Organizer
      第29回日本炎症・再生医学会
    • Place of Presentation
      都市センターホテル
    • Year and Date
      2008-07-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] イヌ由来歯根膜細胞を使用したスキャフォールドフリー細胞シート作成2008

    • Author(s)
      佐藤郁文, 他
    • Organizer
      第51回春季日本歯周病学会学術大会
    • Place of Presentation
      大宮ソニックシティ
    • Year and Date
      2008-04-26
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.twmu.ac.jp/ABMES/CSTEC/ja/sperio

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.twmu.ac.jp/ABMES/csperio

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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