Study of involvement of sensory neurons in bone defect repair in rats with capsaicin-induced sensory denervation
Project/Area Number |
20791488
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
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Research Institution | Tohoku University |
Principal Investigator |
NAKAMURA Megumi 東北大学, 大学院・歯学研究科, 助教 (20431512)
|
Project Period (FY) |
2008 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥5,473,000 (Direct Cost: ¥4,210,000、Indirect Cost: ¥1,263,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,313,000 (Direct Cost: ¥1,010,000、Indirect Cost: ¥303,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 骨 / 修復 / 感覚神経 / カプサイシン / リモデリング / X線画像解析 / real-time PCR / ラット / 修復・再生 |
Research Abstract |
We investigated bone repair in sensory-denervated rats. Nine-week-old male Wistar rats received subcutaneous injections of capsaicin to denervate sensory neurons. Rats treated with the same amount of vehicle served as controls. A standardized bone defect was created on the parietal bone. We measured the amount of repaired bone with quantitative radiographic analysis and the mRNA expressions of osteocalcin and cathepsin K with real-time PCR. The results suggested that capsaicin-induced sensory denervation affects the bone defect repair and remodeling.
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Report
(5 results)
Research Products
(15 results)