Development of odontogenic regenerative therapy by epithelial-mesenchymal interactions using ameloblast and odontoblast-lineage cell lines.
| Project/Area Number |
20791490
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Akita University |
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Principal Investigator |
NAKATA Akira Akita University, 医学部, 助教 (50400510)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 歯の再生医療 / エナメル芽細胞 / 上皮-間葉相互作用 / 象牙芽細胞 / Signal / Scaffold |
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| Research Abstract |
We try to develop the original tooth regenerative therapy by epithelial-mesenchymal interactions in vitro and in vivo using ameloblast, odontoblast-lineage cell line and scaffold which specialized in the tooth regenerative therapy.
In this study, after sub-cutaneous implantation of ameloblast-lineage cell line that cultured three-dimensional in matrigel to athymic nude mice, we ectopically observed enamel epithelium like structure formation and hard tissue construction. We believed that these cell lines are useful tool for clinical tissue engineering technology to repair the tooth
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] 口腔カンジダ症に対するイトラコナゾール内用液の治療効果について2009
Author(s)
石田貴洋, 高野裕史, 中田憲, 伊藤悠, 本間高志, 鈴木正晴, 山下貴史, 大渕真彦, 五十嵐秀光, 海老原龍人, 今野泰典, 佐藤裕子, 福田雅幸
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Journal Title
J Michinoku Dent Soc 40(1・2)
Pages: 47-48
Related Report
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