| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In this study, biological functions of periostin, which was expressed in surrounding areas of tissue-engineered cartilage, was investigated to clarify its effects on chondrocytes and tissue-engineered cartilage. While periostin did not induce proliferation in human auricular chondrocytes cultured in monolayer, it increased the expression of type II collagen in chondrocytes embedded in 1% atelocollagen gel. Furthermore, when tissue-engineered cartilage, which consisted of chondrocytes of periostin knockout mice and PLLA, were syngenically transplanted in the back of wild type mice, the constructs demonstrated reduced accumulation of proteoglycan, suggesting periostin possibly promoted the maturation of tissue-engineered cartilage constructs.
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