Biological functions of periostin expressed in tissue-engineered cartilage and its application for cartilage regeneration.
| Project/Area Number |
20791493
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUJIHARA Yuko The University of Tokyo, 医学(系)研究科(研究院), 特任助教 (50466744)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 再生医療 / 軟骨再生 / 移植 / ペリオスチン / 再生医学 / 再生軟骨 |
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| Research Abstract |
In this study, biological functions of periostin, which was expressed in surrounding areas of tissue-engineered cartilage, was investigated to clarify its effects on chondrocytes and tissue-engineered cartilage. While periostin did not induce proliferation in human auricular chondrocytes cultured in monolayer, it increased the expression of type II collagen in chondrocytes embedded in 1% atelocollagen gel. Furthermore, when tissue-engineered cartilage, which consisted of chondrocytes of periostin knockout mice and PLLA, were syngenically transplanted in the back of wild type mice, the constructs demonstrated reduced accumulation of proteoglycan, suggesting periostin possibly promoted the maturation of tissue-engineered cartilage constructs.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Transforming Growth Factor-β1 in Combination with Fibroblast Growth Factor-2 and Insulin-like Growth Factor-I for Chondrocyte Proliferation Culture and Cartilage Regenerative Medicine.2009
Author(s)
Ogasawara T, Ohba S, Fujihara Y, Takahashi T, Liu G, Chikazu D, Suenaga H, Chung UI, Yoda T, Mori Y, Susami T, Takato T, Hoshi K
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Journal Title
Asian J Oral Maxillofac Surg 21
Pages: 18-26
Related Report
Peer Reviewed
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[Journal Article] Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coated plates.2009
Author(s)
Liu G, Iwata K, Ogasawara T, Watanabe J, Fukazawa K, Ishihara K, Asawa Y, Fujihara Y, Chung UI, Moro T, Takatori Y, Takato T, Nakamura K, Kawaguchi H, Hoshi K
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Journal Title
J Biomed Mater Res A 92
Pages: 1273-1282
Related Report
Peer Reviewed
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