Search for new susceptibility gene controlled of cleft and/or palate development using p53 knock-out mice

Research Project

Project/Area Number	20791499
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Niigata University
Principal Investigator	KODAMA Yasumiktsu Niigata University, 医歯学総合病院, 助教 (90419276)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords	口唇口蓋裂 / p53遺伝子 / アポトーシス / 感受性遺伝子 / ノックアウトマウス
Research Abstract	We suffer from MSM p53 knockout mouse production. We continue a study continuously and are planning to achieve a purpose. Whereas the condition establishment of p53 typing and the PCR which we used microsatellite marker for was almost decided. We aim at the stable typing by adjusting a condition sequentially.It have not lead to the identification of new susceptibility gene for cleft lip and palate promotion yet, but the identification of the applicable gene cluster, analysis of function, likelihood of the contribution to a clinical were shown in future by continuing this study.

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