Histologic study on the cellular events during distraction osteogenesis using the tissue-engineered osteogenic materials.

• Project/Area Number: 20791507
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Nagoya University
• Principal Investigator: KINOSHITA Kazuhiko Nagoya University, 医学部附属病院, 医員 (40467296)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 顎骨延長法 / 骨髄間質細胞 / 組織工学 / 歯肉 / 骨延長法

Research Abstract

The rabbits received an injection of cultured bone marrow stromal cells(BMSCs) or BMP-2 into the distracted tissue at the end of distraction. Each distracted mandible and gingival tissue were evaluated at 2, 4, and 6 weeks after the end of distraction.
This study showed that an injection of tissue-engineered osteogenic material at the end of distraction promoted new bone formation following a higher rate of distraction (3.0 mm / day). However, these materials might not affect distracted gingival tissue.

Research Products

• [Journal Article] Effects of cortical bone perforationon periosteal distraction : an experimental study in the rabbit mandible. (2009)
  • Author(s): Tomoo Oda, Kazuhiko Kinoshita., et al.
  • Journal Title: J Oral Maxillofac Surg. 67(7) Pages: 1478-1485
  • Peer Reviewed
• [Presentation] ウサギ頭頂部造成モデルにおける自己組織化ペプチドハイドロゲルの効果 (2010)
  • Author(s): 池野正幸、木下一彦, 他
  • Organizer: 第55回日本口腔外科学会総会・学術大会
  • Place of Presentation: 幕張
  • Year and Date: 2010-10-17
• [Presentation] ウサギ頭頂部造成モデルにおける自己組織化ペプチドハイドロゲルの効果 (2010)
  • Author(s): 池野正幸
  • Organizer: 第55回 日本口腔外科学会総会・学術大会
  • Place of Presentation: 幕張,千葉
  • Year and Date: 2010-10-17
• [Presentation] ウサギ頭頂部骨移植モデルを用いた骨造成における遮蔽財の検討 (2010)
  • Author(s): 池野正幸、木下一彦, 他
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-19
• [Presentation] 骨延長部の骨形成過程におけるSDF-1/CXCR4システムの役割 (2010)
  • Author(s): 藤尾正人、木下一彦, 他
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-19
• [Presentation] The effect of shields on the bone augmentation model in the rabbit calvariae. (2009)
  • Author(s): Masayuki Ikeno, Kazuhiko Kinoshita, et al.
  • Organizer: 13^<th> Biennial Internal Congress incorporating the Paris Distraction Symposium
  • Place of Presentation: Oxford, U.K.
  • Year and Date: 2009-09-26
• [Presentation] Transplantation of the tissue -engineered osteogenic material to the distracted callus in the rabbit maxilla. (2009)
  • Author(s): Kazuhiko Kinoshita., et al.
  • Organizer: 13^<th> Biennial Internal Congress incorporating the Paris Distraction Symposium
  • Place of Presentation: Oxford, U.K.
  • Year and Date: 2009-09-26
• [Presentation] Internal transport distraction for mandibular reconstruction. (2009)
  • Author(s): Hideharu Hibi, Kazuhiko Kinoshita., et al.
  • Organizer: 13^<th> Biennial Internal Congress incorporating the Paris Distraction Symposium
  • Place of Presentation: Oxford, U.K.
  • Year and Date: 2009-09-26
• [Presentation] Transplantation of a tissue -engineered osteogenic material to the distracted callus in the rabbit maxilla (2009)
  • Author(s): 木下一彦
  • Organizer: The ISCFS XIII Biennial International Congress and Distraction Symposium
  • Place of Presentation: オックスフォード 英国
  • Year and Date: 2009-09-26
• [Presentation] ウサギ頭頂部骨移植モデルを用いた骨造成における遮蔽財の検討 (2009)
  • Author(s): 池野正幸、木下一彦, 他
  • Organizer: 第63回日本口腔科学会学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2009-04-17
• [Remarks] ホームページ等