| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
I aimed the establishment of experimental animal model of the oxidative stress in the central nerve system (CNS) to research the protective effect of anesthetics to oxidative stress in CNS. I made the rat Hemorrhage shock model that was initiated by bleeding, kept low blood pressure for 1 hour, and returned to normal blood pressure. After that, I studied whether oxidative stress was present in CNS. In the result, I could detect the expression of Heme Oxygenase-1 that was oxidative stress-specific enzyme in CNS. This means that Hemorrhage shock model is the experimental animal model of the oxidative stress in CNS.
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