| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
In this study, we generated specific antibodies against the human GDDI protein. As an essential step toward elucidating the molecular functions of GDDI gene, we also made the GDD1 expression vector and had been tried to establish stable expression system of GDDI protein in the cultured cell. The GDDI protein was easily degraded in the cell, and the protein detection was difficult. Therefore, the physiological and molecular biochemical functions of GDDI gene have been uncertain. However, our recent study led to identify that GDD1 gene was also the responsible gene of proximal limb girdle muscular dystrophy (LGMD2L) of which the symptom was a muscular atrophy, and the GDDI gene was demonstrated to play important roles in the skeletal muscle homeostasis maintenance by the expression experiment using the myoblastic cell line.
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