Analysis of inflammatory responses associated with oral chronic inflammation in oral keratinocytesand fibroblasts.
| Project/Area Number |
20791518
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
NISHI Hiromi Hiroshima University, 病院, 助教 (70403558)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 炎症性口腔粘膜疾患 / 口腔粘膜上皮細胞 / 歯肉線維芽細胞 / Th1サイトカイン / Th2サイトカイン |
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| Research Abstract |
The JAK/STAT pathway activated by INF-γ in oral keratinocytes and fibroblasts undertook an expressional control depending on cells and cytokines. Furthermore, the pathway affected to expression of chemokine such as CXCL10.
It was expected to lead to not only the clarification of oral chronic inflammation appearance of disease mechanism but also new treatment and the development of the inspection method.
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Report
(3 results)
Research Products
(8 results)
