Developomental study of molecular target therapy to oral cancer with FGFBP.

• Project/Area Number: 20791519
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: SHINTANI Tomoaki Hiroshima University, 病院, 助教 (90403518)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 分子標的治療 / FGF結合蛋白

Research Abstract

HBp17 siRNA was synthesized and transfected. Control scrambled siRNA was used. Quantitative RT-PCR analysis was performed. Then, we performed westernblotting analysis to compare with HBp17 in cell and culture media at 48hrs after transfection. Finaly growth assay was done. In HBp17-transfected cells, HBp17 mRNA expression was significantly decreased compared with control. HBp17 protein expression was also decreased in cell or culture media. In roliferation assay, growth of HBp17 siRNA trasfected-OSCC KA, UE and NA was inhibited.

Research Products

• [Journal Article] The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma : consistent data from cell lines, orthotopic models, and human tumor samples (2009)
  • Author(s): Lewis VO
  • Journal Title: Cancer Research 69 Pages: 1995-1999
  • Peer Reviewed
• [Journal Article] The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma : consistent data from cell lines, orthotopic models, and human tumor samples (2009)
  • Author(s): Lewis VO
  • Journal Title: Cancer Research 68 Pages: 1995-1999
  • Peer Reviewed
• [Journal Article] 著名な脂肪化を伴った頬部血管平滑筋腫の1例 (2008)
  • Author(s): 新谷智章
  • Journal Title: 日本口腔外科学会誌 54 Pages: 621-625
  • Peer Reviewed
• [Journal Article] 広島大学病院歯科における歯科用金属アレルギー被疑患者を対象としたパッチテストおよび元素分析の過去10年間の集計 (2008)
  • Author(s): 北川雅恵
  • Journal Title: 広島大学歯学会誌 40 Pages: 124-128
  • Peer Reviewed
• [Journal Article] 著明な脂肪化を伴った頬部血管平滑筋腫の1例 (2008)
  • Author(s): 新谷智章
  • Journal Title: 日本口腔外科学会誌 54 Pages: 621-625
  • NAID: 10027089646
  • Peer Reviewed
• [Presentation] FGF結合蛋白FGFBP/HBp17を標的としたRNAiによる口腔扁平上皮癌細胞の増殖抑制効果の検討 (2010)
  • Author(s): 岡崎文彦, 新谷智章, 林堂安貴, 藤井良典, 笛吹恵美子, 虎谷茂昭, 岡本哲治
  • Organizer: 第64回NPO法人日本口腔科学会学術集会
  • Place of Presentation: 札幌プリンスホテル
  • Year and Date: 2010-06-17
• [Presentation] 歯科性組織におけるヘパリン親和性FGF結合蛋白FGFBP/HBp17の免疫組織学的検討新谷智章 (2008)
  • Author(s): 新谷智章
  • Organizer: 第62回日本口腔科学会総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-04-18
• [Presentation] 歯原性組織におけるヘパリン親和性FGF結合蛋白FGFBP/HBp17の免疫組織学的検討 (2008)
  • Author(s): 新谷智章
  • Organizer: 第62回日本口腔科学会総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-04-18