Idenfication and function of specific protein induced by candida albicans from human oral mucosal cell
| Project/Area Number |
20791522
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
OHTA Kouji Hiroshima University, 病院, 助教 (20335681)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Candida albicans / ケモカイン / 口腔粘膜上皮細胞 / 歯肉線維芽細胞 / Camdida albicans |
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| Research Abstract |
Oral mucosal cells are thought to influence host inflammatory responses against Candida albicans(Ca). Addition of Ca live cells to human immortalized oral keratinocytes (RT7) resulted in increases in mRNA levels of multiple chemokines, however not of CX3CL1. In contrast, live and heat-killed Ca caused an increase in CX3CL1 mRNA and protein expression in human immortalized oral fibroblasts (GT1). CX3CL1 mRNA expression in GT1 cells was also enhanced by stimulation with a non-albicans species of Candida. Further, the CX3CL1 chemokine domain showed antifungal activity against C. albicans. CX3CL1 secreted by oral fibroblasts appears to play an important role in oral immune response to C. albicans infection.
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Report
(4 results)
Research Products
(15 results)
