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Idenfication and function of specific protein induced by candida albicans from human oral mucosal cell

Research Project

Project/Area Number 20791522
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionHiroshima University

Principal Investigator

OHTA Kouji  Hiroshima University, 病院, 助教 (20335681)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsCandida albicans / ケモカイン / 口腔粘膜上皮細胞 / 歯肉線維芽細胞 / Camdida albicans
Research Abstract

Oral mucosal cells are thought to influence host inflammatory responses against Candida albicans(Ca). Addition of Ca live cells to human immortalized oral keratinocytes (RT7) resulted in increases in mRNA levels of multiple chemokines, however not of CX3CL1. In contrast, live and heat-killed Ca caused an increase in CX3CL1 mRNA and protein expression in human immortalized oral fibroblasts (GT1). CX3CL1 mRNA expression in GT1 cells was also enhanced by stimulation with a non-albicans species of Candida. Further, the CX3CL1 chemokine domain showed antifungal activity against C. albicans. CX3CL1 secreted by oral fibroblasts appears to play an important role in oral immune response to C. albicans infection.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (15 results)

All 2010 2009 2008

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (4 results)

  • [Journal Article] CX3CL1 expression induced by Candida albicans in oral fibroblasts.2010

    • Author(s)
      Ohta K, Nishi H, et al.
    • Journal Title

      FEMS Immunol Med Microbial 60

      Pages: 179-185

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological evaluation including cytokeratinl3 and Ki-67 in the border between Lugol-stained and -unstained areas.2010

    • Author(s)
      Ohta K, Ogawa K, Ono S, et al.
    • Journal Title

      Oncology reports 24

      Pages: 9-14

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of factors related to implant stability detected by wireless resonance frequency analysis device.2010

    • Author(s)
      Ohta K,Takechi M, et al.
    • Journal Title

      Journal of Oral Rehabilitation 37

      Pages: 131-137

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wound healing effects of gingival fibroblasts cultured in animal-free medium.2010

    • Author(s)
      NISHI H, Ohta K, TAKECHI M, et al.
    • Journal Title

      Oral Diseases 16

      Pages: 438-444

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] CX3CL1 expression induced by Candida albicans in oral fibroblasts2010

    • Author(s)
      Ohta K
    • Journal Title

      FEMS immunology and medicalmicrobiology

      Volume: 60 Pages: 179-185

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of TPX2 in salivary gland carcinomas.2009

    • Author(s)
      Shigeishi H, Ohta K, Hiraoka M, et al.
    • Journal Title

      Oncol Rep 21

      Pages: 4-341

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of the receptor for hyaluronan-mediated motility, correlates with expression of microtubule-associated protein in human oral squamous cell carcinomas.2009

    • Author(s)
      Shigeishi H, Fujimoto S, Hiraoka M, Ono S, Taki M, Ohta K, et al.
    • Journal Title

      Int J Oncol 34

      Pages: 1565-1571

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of CXCL9/10/11 in oral keratinocytes and fibroblasts.2008

    • Author(s)
      Ohta K, Shigeishi H, Taki M.
    • Journal Title

      J Dent Res 87

      Pages: 1160-1165

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of epiregulin, a novel epidermal growth factor ligand associated with prognosis in human oral squamous cell carcinomas2008

    • Author(s)
      Shigeishi H, Higashikawa K, Hiraoka M, Mitani Y, Ohta K., et al.
    • Journal Title

      Oncol Rep. 19

      Pages: 1557-1564

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of CENP-H gene in human salivary gland carcinomas.2008

    • Author(s)
      Shigeishi H, Yoshitsugu M, Ono S, Higashikawa K, Ohta K, et al.
    • Journal Title

      Oral Science International 5

      Pages: 43-51

    • NAID

      10024185909

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of CXCL 9/10/11 in oral keratinocytes and fibroblasts2008

    • Author(s)
      Kouji, Ohta, et.al.
    • Journal Title

      Journal of dental research 87

      Pages: 1161-1165

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] candida albicansによる歯肉線維芽細胞のFractalkine(CX3CL1)発現誘導と機能2009

    • Author(s)
      太田耕司, 西裕美, 他
    • Organizer
      第62回日本口腔科学会学会集会
    • Place of Presentation
      神奈川
    • Year and Date
      2009-06-06
    • Related Report
      2010 Final Research Report
  • [Presentation] candida albicansによる口腔粘膜上皮細胞,線維芽細胞におけるFractalkine(CX3CL1)発現の検討2009

    • Author(s)
      太田耕司, 西裕美, 他
    • Organizer
      第63回日本口腔科学会学会集会
    • Place of Presentation
      浜松
    • Year and Date
      2009-04-16
    • Related Report
      2010 Final Research Report
  • [Presentation] candida albicansによる不死化口腔粘膜上皮細胞,線維芽細胞における特異的ケモカイン発現誘導2008

    • Author(s)
      太田耕司, 西裕美, 他
    • Organizer
      第62回日本口腔科学会学会集会
    • Place of Presentation
      福岡
    • Year and Date
      2008-04-17
    • Related Report
      2010 Final Research Report
  • [Presentation] candida albicansによる口腔粘膜上皮細胞,線維芽細胞における特異的ケモカイン発現誘導2008

    • Author(s)
      太田耕司, 西裕美, 他
    • Organizer
      第18回日本口腔粘膜学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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