Fabrication of the scaffold with growth factor release and experimental study of the scaffold for bone regeneration

• Project/Area Number: 20791528
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: TATEHARA Seiko The University of Tokushima, 医学部・歯学部附属病院, 助教 (90380089)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 生体材料 / 再生医療 / セラミック / 細胞・組織 / 生体材料学

Research Abstract

We have fabricated highly interconnecting, macropouros hybrid scaffolds of poly (lactide-co-glycolide)(PLGA) and apatite cement (AC). The aim of this study was to determine the effectiveness of bFGF on bone regeneration within PLGA-AC scaffold. PLGA-AC scaffolds with bFGF (PLAC-F) were implanted into the drill hole defects of 4 mm in diameter were made in the tibiae of rabbits. After 6 weeks, PLAC-F scaffolds were significantly infiltrated with new more bone tissue in the medullary region. These findings demonstrate that PLAC scaffold incorporated with bFGF has a great advantage for bone tissue engineering.

Research Products

• [Journal Article] Osteoporosis influences the early period of the healing after distraction osteoeenesis in a Rat Osteonrotic Model (2010)
  • Author(s): 舘原誠晃, 他
  • Journal Title: Journal of Cranio-Maxillofacial Surgery (In press)
  • Peer Reviewed
• [Journal Article] Effect of FGF-2 and melatonin on implant bone healing:a histomorphomotric study (2008)
  • Author(s): 武知正晃舘原誠晃, 他
  • Journal Title: J Mater Sci Mater Med. 19
  • Peer Reviewed
• [Journal Article] Osteoporosis influences the early period of the healing after distfaction osteogenesis in a Rat Osteoprotic Model
  • Author(s): 舘原謹晃, 他
  • Journal Title: Journal of Cranio-Maxillofacial Surgery (in press)
  • Peer Reviewed
• [Presentation] 低結晶性炭酸含有アパタイトの顎骨再建への応用に関する基礎的研究骨組織内での長期評価 (2009)
  • Author(s): 舘原誠晃, 他
  • Organizer: 第63回日本口腔外科学会総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2009-10-10
• [Presentation] 低結晶性炭酸含有アパタイトによるサイナスリフトへの基礎的研究 (2009)
  • Author(s): 高野栄之、舘原誠晃, 他
  • Organizer: 第39回日本口腔インプラント学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2009-09-27
• [Presentation] 低結晶性炭酸含有アパタイトの顎骨再建への応用に関する基礎的研究ウサギ大腿骨内での組織学的検討 (2009)
  • Author(s): 舘原誠晃, 他
  • Organizer: 第63回日本口腔科学会学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2009-04-17
• [Presentation] 低結晶性炭酸含有アパタイトの顎骨再建への応用に関する基礎的研究ウサギ大腿骨内での組織学的検討 (2009)
  • Author(s): 舘原誠晃
  • Organizer: 第63回日本口腔科学会学術集会
  • Place of Presentation: アクトシティ浜松(静岡)
  • Year and Date: 2009-04-17