Study on the role of dendritic cells in oral autoimmune diseases

• Project/Area Number: 20791530
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: KAKEHASHI Hiroe Kyushu University, 病院・顎口腔外科, 医員 (30452775)
• Co-Investigator(Renkei-kenkyūsha): KAWANO Shintaro 九州大学, 病院・顎口腔外科, 助教 (00398067)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 樹状細胞 / 自己免疫疾患 / 扁平苔癬 / シェーグレン症候群 / 白板症 / 扁平上皮癌 / 免疫療法 / 癌幹細胞

Research Abstract

For target lead to immunotherapy using dendritic cells, or how to get involved in the occurrence of oral Squamous Cell Carcinoma (OSCC), differentiation and proliferation, recognizing Δ Np63 normal oral mucosa epithelial stem cell markers in the research and study, the research has been conducted. As a result, heavy degree of epithelial dysplasia suggested that from easy-to-cancer by OSCC to Δ Np63 appearance are involved in the occurrence of OSCC are higher degrees as the expression of Δ Np63 higher was also the expression of epithelial dysplasia. In addition, was considered Δ Np63 is involved in OSCC cell differentiation and proliferation.

Research Products

• [Presentation] Possible involvement of ΔNp63 in proliferation and differentiation of OSCC. (2010)
  • Author(s): Ryota MATSUBARA, Shintaro KAWANO, Hiroe KAKEHASHI, Seiji NAKAMURA, et al.
  • Organizer: 10^<th> Congress of the European Association of Oral Medicine incorporating the World Workshop on Oral Medicine
  • Place of Presentation: London, England
• [Presentation] Immunohistochemical localization of p75NTR in oral leukoplakia and OSCC. (2010)
  • Author(s): Takahiro KIYOSUE, Shintaro KAWANO, Hiroe KAKEHASHI, Seiji NAKAMURA, et al.
  • Organizer: 10^<th> Congress of the European Association of Oral Medicine incorporating the World Workshop on Oral Medicine
  • Place of Presentation: London, England
• [Presentation] 口腔扁平上皮癌におけるΔNp63の発現と機能 (2010)
  • Author(s): 松原良太、川野真太郎、梯裕恵、中村誠司, ら
  • Organizer: 第64回日本口腔科学会総会・学術大会
  • Place of Presentation: 北海道
• [Presentation] 口腔扁平上皮癌におけるΔNp63の発現と機能 (2010)
  • Author(s): 松原良太、川野真太郎、梯裕恵、中村誠司, ら
  • Organizer: 第55回日本口腔外科学会総会・学術大会
  • Place of Presentation: 千葉
• [Presentation] 口腔扁平上皮癌におけるΔNp63の発現と機能 (2010)
  • Author(s): 松原良太
  • Organizer: 第64回 日本口腔科学会総会・学術大会
  • Place of Presentation: 札幌プリンスホテル(北海道)
• [Presentation] 口腔扁平上皮癌におけるΔNp63の発現と機能 (2010)
  • Author(s): 松原良太
  • Organizer: 第55回 日本口腔外科学会総会・学術大会
  • Place of Presentation: 幕張メッセ(千葉)
• [Presentation] Possible involvement of ΔNp63 in proliferation and differentiation of OSCC. (2010)
  • Author(s): Ryota MATSUBARA
  • Organizer: 10^<th> Congress of the European Association of Oral Medicine in corporating the World Workshop on Oral Medicine
  • Place of Presentation: Central Hall Westminster (London, England)
• [Presentation] Immunohistochemical localization of p75NTR in oral leukoplakia and OSCC. (2010)
  • Author(s): Takahiro KIYOSUE
  • Organizer: 10^<th> Congress of the European Association of Oral Medicine in corporating the World Workshop on Oral Medicine
  • Place of Presentation: Central Hall Westminster (London, England)
• [Presentation] 下顎枝垂直骨切り術を行った骨格性下顎前突症を伴う軟骨無形性症患者の1例 (2009)
  • Author(s): 梯裕恵
  • Organizer: 第19回日本顎変形症学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-04
• [Presentation] 口腔扁平上皮癌における上皮幹細胞マーカー(p63、p75NTR)に関する研究 (2009)
  • Author(s): 松原良太、川野真太郎、梯裕恵、中村誠司, ら
  • Organizer: 第54回日本口腔外科学会総会・学術大会
  • Place of Presentation: 北海道
• [Presentation] 顎下部腫瘤として発現し急速に増悪したMalignant spindle cell tumorの1例 (2008)
  • Author(s): 梯裕恵
  • Organizer: 第53回日本口腔外科学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2008-10-20