| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
【Objective】
Mikulicz's disease (MD) has been considered to be a subtype of Sjogren's syndrome (SS). However, recent studies have indicated that MD shows high serum IgG4 concentration, and suggested that MD is an IgG4 related systemic disease and distinguishable from SS. In addition, It has been reported that both IL-4 and IL-10 upregulate induction of IgG4, whereas inhibition of IgE. Therefore, we examined the expression of these cytokines in SS and MD patients.
【Materials and Methods】
Fifteen and 18 patients with MD and SS, respectively, referred to Kyushu University Hospital between 1993 and 2009, were included in the study. The following items were examined; 1.subsets of the infiltrating lymphocytes, 2. expression of Th1, Th2, and Treg type cytokines, 3. relationship between IgG4/IgG ratio and expression of IL-4 or IL-10 in the salivary glands.
【Results】
SS showed the lymphocytes infiltration of various subsets and the increased expression of both Th1 and Th2 types cytokines, while MD showed the selective IgG4+ B cell and Treg infiltration and the increased expression of Th2 and Treg type cytokines. Both IL-4 and IL-10 were closely associated with IgG4 production.
【Conclusion】
These results suggest that the pathogenesis of MD is apparently different from that of SS, and that MD might not be s subtype of SS. Furthermore, Th2 and Treg type cytokines were involved in not only the initiation but also the progression of MD
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