Elucidation of the salivary gland differentiation system which aimed at the salivary gland regenerative medicine

• Project/Area Number: 20791533
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: IKARI Tatsuya 九州大学, 大学病院, 助教 (70380467)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 唾液腺 / 再生医療 / 幹細胞

Research Abstract

We established a model three-imensional reconstruction of tissue culture cell separation from the submandibular gland primordia in this study. Rebuild their organization, were also admitted the expression of aquaporin as a marker or terminal. differentiation. This phenomenon, in the salivary gland tissue has shown that it contains a group of cells s should be called stem cells. Brachury is a transcription factor T-box is a gene required in mesoderm rormation, expression Brachury in the normal salivary glands, recognized the increased expression of a sudden on embryonic day 13. 5, after embryonic day 14. 5 the amount of its expression decreased proved that.