Identification of new factors concerned with anti-cancer drugs resistant using proteome analysis and clinical application of its factors.

• Project/Area Number: 20791535
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kumamoto University
• Principal Investigator: YOSHITAKE Yoshihiro Kumamoto University, 医学部附属病院, 助教 (00423682)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 癌 / 歯学 / プロテオーム / 蛋白質 / 遺伝子 / ゲノム / 細胞・組織 / マイクロアレイ

Research Abstract

In present, we identified novel factors concerned with anti-cancer drug resistance using cDNA microarray analysis. We identified some anti-cancer drug resistant factors, but we can't still report in a paper. In a few days we will write up experimental data in a paper.
In the future, we hope to make target therapy regents to reject oral cancers. We are considering that custom-made vaccine using anti-cancer drugs considering her genetic background is possible.

Research Products

• [Journal Article] Haemophilic pseudotumour of the mandible in a 5-year-old patient. (2011)
  • Author(s): Yoshitake Y, Nakayama H, Takamune Y, Yasunaga M, Hiraki A, Shinohara M.
  • Journal Title: Int J Oral Maxillofac Surg Volume: 40 Pages: 120-123
  • Peer Reviewed
• [Journal Article] Phase II Study of Preoperative Concurrent Chemoradiation Therapy with S-1 in Patients with T4 Oral Squamous Cell Carcinoma. (2010)
  • Author(s): Tomoko Nomura, Ryuji Murakami, Ryo Toya, Keiko Teshima, Aya Nakahara, Toshinori Hirai, Akimitsu Hiraki, Hideki Nakayama, Yoshihiro Yoshitake, Kazutoshi Ota, Takehisa Obayashi, Yasuyuki Yamashita, Natsuo Oya, Masanori Shinohara
  • Journal Title: Int J Radiat Oncol Biol Phys. 76 Pages: 1347-1352
  • Peer Reviewed
• [Journal Article] Haemophilic pseudotumour of the mandible in a 5-year-old patient. (2010)
  • Author(s): Yoshitake Y, Nakayama H, Takamune Y, Yasunaga M, Hiraki A, Shinohara M.
  • Journal Title: Int J Oral Maxillofac Surg 40 Pages: 120-123
  • Peer Reviewed
• [Journal Article] PTCH1遺伝子のミスセンス変異が認められた母斑基底細胞癌症候群の1例 (2010)
  • Author(s): 吉武義泰、中山秀樹、福間大喜、尾木秀直、平木昭光、篠原正徳
  • Journal Title: 日本口腔外科学会誌 56 Pages: 730-734
  • NAID: 10027844265
  • Peer Reviewed
• [Journal Article] PTCH1遺伝子のミスセンス変異が認められた母斑基底細胞癌症候群の1例 (2010)
  • Author(s): 吉武義泰、中山秀樹、福間大喜、尾木秀直、平木昭光、篠原正徳
  • Journal Title: 日本口腔外科学会誌 Volume: 56 Pages: 730-734
  • NAID: 10027844265
  • Peer Reviewed
• [Journal Article] Phase II Study of Preoperative Concurrent Chemoradiation Therapy with S-1 in Patients with T4 Oral Squamous Cell Carcinoma. (2010)
  • Author(s): Tomoko Nomura, Ryuji Murakami, Ryo Toya, Keiko Teshima, Aya Nakahara, Toshinori Hirai, Akimitsu Hiraki, Hideki Nakayama, Yoshihiro Yoshitake, Kazutoshi Ota, Takehisa Obayashi, Yasuyuki Yamashita, Natsuo Oya, Masanori Shinohara
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 76 Pages: 1347-1352
  • Peer Reviewed
• [Journal Article] Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma. (2009)
  • Author(s): Shinriki S, Jono H, Ota K, Ueda M, Kudo M, Ota T, Oike Y, Endo M, Ibusuki M, Hiraki A, Nakayama H, Yoshitake Y, Shinohara M, Ando Y.
  • Journal Title: Clinical Cancer Research 17 Pages: 5426-5434
  • Peer Reviewed
• [Journal Article] Phase II Study of Preoperative Concurrent Chemoradiation Therapy with S-1 in Patients with T4 Oral Squamous Cell Carcinoma. (2009)
  • Author(s): Tomoko Nomura, Ryuji Murakami, Ryo Toya, Keiko Teshima, Aya Nakahara, Toshinori Hirai, Akimitsu Hiraki, Hideki Nakayama, Yoshihiro Yoshitake, Kazutoshi Ota, Takehisa Obayashi, Yasuyuki Yamashita, Natsuo Ova, Masanori Shinohara
  • Journal Title: Int J Radial Oncol Biol Phys. 5 Pages: 1347-1352
  • Peer Reviewed
• [Journal Article] Aberrant expression of serum amyloid A in head and neck squamous cell carcinoma. (2009)
  • Author(s): Shinriki S, Ueda M, Ota K, Nakamura M, Kudo M, Ibusuki M, Kim J, Yoshitake Y,Fukuma D, Jono H, Kuratsu JI, Shinohara M, Ando Y.
  • Journal Title: J Oral Pathol Med. 1 Pages: 41-47
  • Peer Reviewed
• [Journal Article] 経耳下腺的顔面神経直視下進入法にて切除した関節突起部骨軟骨腫の1例 (2008)
  • Author(s): 吉武博美
  • Journal Title: 日本口腔外科学会雑誌 54 Pages: 567-571
  • Peer Reviewed
• [Presentation] URLC10とTTKペプチドを用いた癌ワクチン療法-臨床試験について- (2011)
  • Author(s): 吉武義泰
  • Organizer: 日本口腔腫瘍学会
  • Place of Presentation: 熊本崇城大学市民ホール
  • Year and Date: 2011-01-27
• [Presentation] Phase I/II clinical trial of cancer vaccine therapy using A3243 and C7457 peptides for locally advanced, metaatatic, or unresectable oral cancer (2010)
  • Author(s): 中元雅史, 吉武義泰, 中山秀樹, 安永真子, 田中拓也, 永田将士, 福間大喜, 平木昭光, 濱田哲暢, 吉田浩二, 角田卓也, 齊藤秀行, 西村泰治, 中村祐輔, 篠原正徳
  • Organizer: 日本癌治療学会
  • Place of Presentation: 京都 京都国際会議場
  • Year and Date: 2010-10-29
• [Presentation] Phase I/II clinical trial of peptide vaccine therapy for locally advanced, metaatatic, or unresectable oral cancer (2010)
  • Author(s): 吉武義泰, 中山秀樹, 中元雅史, 安永真子, 田中拓也, 永田将士, 福間大喜, 川原健太, 中川純泰, 大田宜彦, 高宗康隆, 尾木秀直, 太田和俊, 平木昭光, 篠原正徳
  • Organizer: 日本口腔外科学会
  • Place of Presentation: 千葉幕張メッセ
  • Year and Date: 2010-10-17
• [Presentation] Phase I/II clinical trial of cancer vaccine therapy using A3243 and C7457 peptides for locally advanced, metaatatic, or unresectable oral cancer (2010)
  • Author(s): 吉武義泰, 中山秀樹, 中元雅史, 安永真子, 福間大喜, 田中拓也, 永田将士, 平木昭光, 濱田哲暢, 齊藤秀行, 吉田浩二, 角田卓也, 中村祐輔, 西村泰治, 篠原正徳
  • Organizer: 日本口腔外科学会
  • Place of Presentation: 熊本 崇城大学市民ホール
  • Year and Date: 2010-07-23
• [Presentation] Clinical study with cancer vaccine therapy using TTK and Ly-6K peptides for advanced oral cancer patients. (2009)
  • Author(s): 吉武義泰・中山秀樹・濱田哲暢・福間大喜・田中拓也・永田将士・高宗康隆・吉田遼司・西村泰治・中村祐輔・篠原正徳
  • Organizer: 第68回日本癌学会学術大会
  • Place of Presentation: 横浜 パシフィコ横浜
• [Presentation] 進行・再発口腔癌におけるTTKおよびLy-6Kを標的としたペプチドワクチン療法の第I相試験 (2009)
  • Author(s): 吉武義泰・田中拓也・福間大喜・上野啓之・川原健太・尾木秀直・永田将士・平木昭光・太田和俊・中山秀樹・篠原正徳
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌 コンベンションセンター
• [Presentation] シェーグレン症候群患者におけるミッドカインの発現についての検討 (2009)
  • Author(s): 吉武義泰・田中拓也・中山秀樹・永田将・吉田遼司・尾木秀直・川原健太・上野啓之・福間大喜・高宗康隆・太田和俊・平木昭光・篠原正徳
  • Organizer: 第18回日本シェーグレン症候群学会
  • Place of Presentation: 福岡 九州大学
• [Presentation] Clinical study of chemoradiotherapy with S-1 for inoperative cases of oral souamous cell carcinoma (2008)
  • Author(s): Yoshihiro Yoshitake
  • Organizer: XIX Cranio-Maxillo-Facial Surgery
  • Place of Presentation: ボローニャ・イタリア
• [Presentation] Clinical study of chemoradiotherapy with S-1 for inoperative cases of oral sauamous cell carcinoma (2008)
  • Author(s): Yoshihiro Yoshitake
  • Organizer: 58 KONGRESS DER DEUTSCHEN GESELLSCHAFT FURMUND-, KIEFER-UND GESICHTSCHIRURGIE
  • Place of Presentation: ミュンスター・ドイツ