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The fundamental study of correlation between expression of VEGF and lymphmetastasis of oral squamous cell carcinoma

Research Project

Project/Area Number 20791537
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

ISHIDA Takayuki  Kyushu University, 医学部・歯学部附属病院, 医員 (20404501)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords口腔扁平上皮癌 / リンパ節転移 / VEGF / 低酸素 / MMP / 細胞培養 / 免疫染色 / VEFF
Research Abstract

The human oral squamous cell carcinoma cell lines, HSC-2 and HSC-4 cultured under normaxia (20%O_2, 5%CO_2) and hypoxia (5%O_2, 5%CO_2, 37%). The expression of VEGF was assesed by immunohistocheical staining and RT-PCR. In imumunohisotcehiminal staining, the expression of VEGF-C was stronger under hypoxia rather than normaxia of each cell line. In RT-PCR, the expression of VEGF-C and MMP-9 were increase under hypoxia. Therefore this result suggests VEGF-C induced by hypoxia may increase ability of metasatsis in oral squamous cell carcinoma.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (7 results)

All 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] Upregulation of Notch pathway molecules in oral squamous cell carcinoma2010

    • Author(s)
      Hiroshi Hijioka, Takao Setoguchi, Akihiko MIyawaki, HUI GAO, Takayuki Ishida, Seturo Komiya, NOrifumi Nakamura.
    • Journal Title

      Interational journal of oncology 36

      Pages: 817-22

    • NAID

      120005342570

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SUVmax of FDG-PET correlates with the effects of neoadjuvant chemotherapy for oral squamous cell carcinoma.2010

    • Author(s)
      Akihiko Miyawaki, Ryuji Ikeda, Hroshi Hjioka, Takayuki Ishida, Mina Ushiyama, Eturo Nozoe, Norifumi Nakamura.
    • Journal Title

      Oncology reports 23

      Pages: 1205-12

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SUVmax of FDG-PET correlates with the effects of neoadjuvant chemoradiotherapy for oral squamous cell carcinoma2010

    • Author(s)
      Miyawaki A, Ikeda R, Hijioka H, Ishida T, Ushiyama M, Nozoe E, Nakamura N.
    • Journal Title

      Oncology reports 23

      Pages: 1205-1212

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肥厚性カンジダ症に対するイトラコナゾール内用液(ITCZ-S)の使用経験2009

    • Author(s)
      石田喬之、宮脇昭彦、五味暁憲、上川善昭、中村典史
    • Organizer
      第19回日本口腔粘膜学会総会
    • Place of Presentation
      神奈川
    • Year and Date
      2009-06-06
    • Related Report
      2009 Final Research Report
  • [Presentation] 舌下腺悪性腫瘍の画像所見~耳下腺・顎下腺悪性腫瘍との比較~2009

    • Author(s)
      石田喬之, 河津俊幸, 吉浦一紀
    • Organizer
      第28回日本歯科放射線学会関西・九州合同地方会
    • Place of Presentation
      鹿児島
    • Related Report
      2009 Final Research Report
  • [Presentation] 当科における口腔扁平上皮癌患者の頸部リンパ節転移の診断精度に関する検討2008

    • Author(s)
      比地岡浩志、石田喬之、宮脇昭彦、野添悦郎、馬嶋秀行、中村典史
    • Organizer
      第12回九州地区口腔癌研究会学術講演
    • Place of Presentation
      宮崎
    • Year and Date
      2008-09-05
    • Related Report
      2009 Final Research Report
  • [Presentation] 口腔扁平上皮癌におけるNotchシグナルの発現とその意義2008

    • Author(s)
      比地岡浩志、宮脇昭彦、石田喬之、中村典史
    • Organizer
      第62回日本口腔科学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-04-17
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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