| Project/Area Number |
20791540
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
KAI Aya Kyushu Dental College, 歯学部, 特別研修員 (80453231)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 炎症 / 癌 / 異常疼痛 / インドメタシン / 癌性疼痛 / 炎症性疼痛 / 神経幹細胞 / 神経栄養因子 / 三叉神経脊髄路核尾側亜核 / P物質 / カルシトニン遺伝子関連ペプチド / 脳・神経 / 再生医学 |
|---|
| Research Abstract |
Orofacial cancer rat model exhibits allodynia and hyperalgesia, but it is unclear whether or not the cancer-induced pains are secondarily evoked by cancer-induced inflammation. To address the question, we compared the effects of an anti-inflammatory drug, indomethacin, on abnormal pain in the orofacial inflammation and cancer models. From results, it is suggested that pains in the orofacial cancer model are not significantly mediated by cancer-induced peripheral inflammation although there is a slight involvement.
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