• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Studies on the immune-response of γδT cells in animal model with osteoporosis taking bisphosphonates.

Research Project

Project/Area Number 20791543
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionSaitama Medical University

Principal Investigator

ABE Takahiro  Saitama Medical University, 医学部, 助教 (20383250)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsゾレドロン酸 / コルチコステロイド / RANKL / OPG / TCR / ゾレドロネート / osteoprotegerin / αβTCR / γδTCR
Research Abstract

The aim of this study was to examine, in a basic setting, changes in receptor activator of NF-kB ligand (RANKL) and osteoprotegerin (OPG), and the expression of T cell receptor (TCR) in mice treated with zoledronate (ZOL) and prednisolone (PSL) and lipopolysaccharide (LPS). C57BL/6, NOD-scid, and NOD-scid transplanted peripheral blood mononuclear cells (PBMC) were used. Peripheral blood samples were obtained to assay for OPG and RANKL. Femur and mandible were prepared for histomorphometric analysis. The microarchitecture of the bone samples was assessed by micro-CT. TCR expression was analyzed by immunohistochemistry. Histomorphometric analysis indicated that OS/BS and OV/BV were lowered by the administration of ZOL. Ob.S/BS and Oc.S/BS were decreased. In the C57BL/6 group taking both of ZOL and PSL, injection of LPS into the oral mucosa increased the levels of serum-RANKL. We showed that combined administration of ZOL with PSL decreased bone turn-over, and furthermore the combination causes a different pattern of TCR expression. These findings suggest that PSL and LPS have differential effects on bone metabolism and the immunoresponse to ZOL.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (31 results)

All 2010 2009 2008

All Journal Article (22 results) (of which Peer Reviewed: 21 results) Presentation (9 results)

  • [Journal Article] Preliminary results of a study comparing conventional radiography with phase-contrast radiography for assessing root morphology of mandibular third molars2010

    • Author(s)
      Sato T, Nakamoto N, Abe T, Fukushima Y, Tomaru Y, Sakata Y, Nakazawa M, Nakamoto A, Kawasaki H, Wada Y, Ohara H, Araki R, Tanaka J, Yoda T
    • Journal Title

      Dentomaxillofac Radiol (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts2010

    • Author(s)
      Sato T, Abe T, Chida D, Nakamoto N, Hori N, Kokabu S, Sakata Y, Tomaru Y, Iwata T, Usui M, Aiko K, Yoda T
    • Journal Title

      FEBSLetters 584

      Pages: 817-824

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary results of a study comparing conventional radiography with phase-contrast radiography for assessing root morphology of mandibular third molars.2010

    • Author(s)
      Sato T
    • Journal Title

      Den tomaxillofac Radiol (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts.2010

    • Author(s)
      Sato T.
    • Journal Title

      FEBSLetters 584

      Pages: 817-824

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IgG4-related sclerosing sialadenitis: Report of 2 cases and review of the literature2009

    • Author(s)
      Abe T, Sato T, Tomaru Y, Sakata Y, Kokabu S, Hori N, Kobayashi A, Yoda T
    • Journal Title

      Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 108(4)

      Pages: 544-550

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term results of surgical therapy for masticatory muscle tendon-aponeurosis hyperplasia accompanied by limited mouth opening2009

    • Author(s)
      Yoda T, Sato T, Abe T, Sakamoto I, Tomaru Y, Omura K, Hatano N, Takato T, Ishii Y
    • Journal Title

      International Journal of Oral and Maxillofacial Surgery 38

      Pages: 1143-1147

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ghost cell odontgenic carcinoma arising in calcifying odontgenic cyct2009

    • Author(s)
      Motosugi U, Ogawa I, Yoda T, Abe T, Sugasawa M, Murata S, Yasuda M, Sakurai T, Shimizu Y, Shimizu M
    • Journal Title

      Ann Diagn Pathol 13

      Pages: 394-397

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] HTLV-1キャリアに発症した舌癌の1例2009

    • Author(s)
      嶋村由美子, 安部貴大, 小林明男, 依田哲也
    • Journal Title

      日本口腔腫瘍学会誌 21(3)

      Pages: 211-216

    • NAID

      10026399659

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] TS-1が著効を示した高齢者下咽頭進行癌の2例2009

    • Author(s)
      高城文彦, 菅澤正, 松村聡子, 盛田恵, 嶋村由美子, 安部貴大, 中平光彦, 肥後隆三郎
    • Journal Title

      第22回関越DIF研究会講演集(癌と化学療法社)

      Pages: 10-13

    • Related Report
      2009 Final Research Report
  • [Journal Article] Long-term results of surgical therapy for masticatory muscle tendon-aponeurosis hyperplasia accompanied by limited mouth opening.2009

    • Author(s)
      Yoda T
    • Journal Title

      In ternational Journal of Oral and Maxillofacial Surgery 38

      Pages: 1143-1147

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IgG4-related sclerosing sialadenitis : Report of 2 cases and reviewof the literature.2009

    • Author(s)
      Abe T
    • Journal Title

      Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 108

      Pages: 544-550

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ghost cell odontgenic carcinoma arising in calcifying odontgeniccyct.2009

    • Author(s)
      Motosugi U
    • Journal Title

      Ann Diagn Pathol 13

      Pages: 394-397

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HTLV-1キャリアに発症した舌癌の1例.2009

    • Author(s)
      嶋村由美子
    • Journal Title

      日本口腔腫瘍学会誌 21

      Pages: 211-216

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nicotine induces cell proliferation in association with cyclin D1 up-regulation and inhibits cell differentiation in association with p53 regulation in a murine pre-osteoblastic cell line2008

    • Author(s)
      Sato T, Abe T, Nakamoto N, Tomaru Y, Koshikiya N, Nojima J, Kokabu S, Sakata Y, Kobayashi A, Yoda T
    • Journal Title

      Biochemical and Biophysical Research Communications 377

      Pages: 126-130

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A randomized controlled trial assessing the effectiveness of professional oral care by dental hyginists2008

    • Author(s)
      Sato T, Abe T, Ichikawa M, Fukushima Y, Nakamoto N, Koshikiya N, Kobayashi A, Yoda T
    • Journal Title

      Int J Dent Hyg 6

      Pages: 63-67

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 自己免疫性膵炎を合併したIgG4関連慢性硬化性顎下腺炎の1例2008

    • Author(s)
      安部貴大, 小林明男, 今井謙一郎, 坂田康彰, 佐藤毅, 依田哲也
    • Journal Title

      日本口腔外科学会雑誌 54(10)

      Pages: 558-562

    • NAID

      10027089355

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 両側に発生したガマ腫の1例2008

    • Author(s)
      嶋村由美子, 小林明男, 安部貴大, 冨高優子, 福島洋介, 依田哲也
    • Journal Title

      日本口腔診断学会雑誌 21(2)

      Pages: 292-296

    • NAID

      10025567390

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 矯正用アンカースクリューを固定源として整復した歯槽骨骨折の1例2008

    • Author(s)
      中澤麻有子, 坂田康彰, 古株彰一郎, 福島洋介, 中本紀道, 安部貴大, 小林明男, 依田哲也
    • Journal Title

      日本口腔外傷学会誌 6(1)

      Pages: 13-18

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨破壊を呈した顎放線菌症1例2008

    • Author(s)
      安部貴大, 今井謙一郎, 坂田康彰, 中本紀道, 小林明男, 依田哲也
    • Journal Title

      日本口腔診断学会誌 21(1)

      Pages: 49-54

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nicotine induces cell proliferation in association with cyclin Dl up-regulation and inhibits cell differentiation in association with p53 regulation in a murine preosteoblastic cell line2008

    • Author(s)
      Sato T
    • Journal Title

      Biochemical and Biophysical Research Communications 377

      Pages: 126-130

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自己免疫性膵炎を合併したlgG4関連慢性硬化性顎下腺炎の1例2008

    • Author(s)
      安部貴大
    • Journal Title

      日本口腔外科学会雑誌 54巻

      Pages: 558-562

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 両側に発生したガマ腫の1例2008

    • Author(s)
      嶋村由美子
    • Journal Title

      日本口腔診断学会雑誌 21巻

      Pages: 292-296

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ZOMETA使用におけるBRONJ対策と対応-歯科・口腔外科の役割について-2010

    • Author(s)
      安部貴大
    • Organizer
      ノバルティス血液セミナー講演
    • Place of Presentation
      大宮
    • Year and Date
      2010-03-05
    • Related Report
      2009 Final Research Report
  • [Presentation] ZOMETA使用におけるBRONJ対策と対応-歯科・口腔外科の役割について-2010

    • Author(s)
      安部貴大
    • Organizer
      ノバルティス血液セミナー
    • Place of Presentation
      大宮市、埼玉県
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] ゾレドロネートおよびコルチコステロイド併用によるRANKL/OPGへの影響2009

    • Author(s)
      安部貴大, 堀直子, 佐藤毅, 嶋村由美子, 小林明男, 依田哲也
    • Organizer
      第54回日本口腔外科学会
    • Place of Presentation
      札幌
    • Year and Date
      2009-10-10
    • Related Report
      2009 Final Research Report
  • [Presentation] ゾレドロネートおよびコルチコステロイド併用によるRANKL/OPGへの影響2009

    • Author(s)
      安部貴大
    • Organizer
      第54回日本口腔外科学会
    • Place of Presentation
      札幌市、北海道
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] BMPの骨芽細胞分化誘導作用におけるSmad1およびSmad4依存的シグナルの解析2008

    • Author(s)
      野島淳也
    • Organizer
      第53回日本口腔外科学会総会
    • Place of Presentation
      徳島
    • Year and Date
      2008-10-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 咀嚼筋腱・腱膜過形成症患者の咬筋腱膜組織における腱マーカー因子の免疫組織学的検討2008

    • Author(s)
      佐藤毅, 安部貴大, 狩野証夫, 古株彰一郎, 田口茂和, 堀直子, 今井謙一郎, 小林明男, 依田哲也
    • Organizer
      第21回日本顎関節学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-07-27
    • Related Report
      2009 Final Research Report
  • [Presentation] IgG4関連疾患と考えられる自己免疫性膵炎合併ミクリッツ病の1例2008

    • Author(s)
      金築真理, 安部貴大, 古株彰一郎, 堀直子, 福島洋介, 佐藤毅, 坂田康彰, 今井謙一郎, 小林明男, 依田哲也
    • Organizer
      第62回日本口腔科学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-04-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Acetylcholineは骨芽細胞の分化を抑制し増殖を促進する2008

    • Author(s)
      佐藤毅, 安部貴大, 中本紀道, 古敷谷昇, 福島洋介, 古株彰一郎, 坂田康彰, 都丸泰寿, 小林明男, 依田哲也
    • Organizer
      第62回日本口腔科学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-04-18
    • Related Report
      2009 Final Research Report
  • [Presentation] BMPの骨芽細胞分化誘導作用におけるSmad1およびSmad4依存的シグナルの解析2008

    • Author(s)
      野島淳也, 安部貴大, 古株彰一郎, 依田哲也
    • Organizer
      第62回日本口腔科学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-04-17
    • Related Report
      2009 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi