| Project/Area Number |
20791544
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
SATO Tsuyoshi Saitama Medical University, 医学部, 助教 (60406494)
|
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | semaphorin / 細胞間ネットワーク / 骨細胞 / 分化 / semaphorinファミリー / 骨芽細胞 / plexinファミリー |
|---|
| Research Abstract |
We have found that osteocytes express plexin A1, A2, A3, B1, B2, C1 and both plexin A1 and plexin A2 increase mRNA expression sequentially. Osteocytes produce semaphorin 3A protein. Semaphorin 3A induces the expression of E11, connexin 43 and DMP1 in osteocyte. Using soft x-ray analysis, we detected high bone mineral in mice whose femur effected with hydrogel with semaphorin 3A in comparison with the control. Taken together, we discovered that semaphorin 3A regulates differentiation and dendrite extension on osteocytes in vitro and also promotes maturation of bone in vivo.
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