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Analysis of functional changes in the surrounding muscle tissue of oral cancer with dysfunction of swallowing

Research Project

Project/Area Number 20791548
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionMeikai University

Principal Investigator

SAKIYAMA Koji  Meikai University, 歯学部, 講師 (50385142)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords舌癌 / ミオシン重鎖 / HMGB1 / SCC7 / SCC7 cell / tongue cancer / Myosin Heavy Chain / mouse / LightCycler / LightCvcler / tongUe canCer
Research Abstract

The reason causing dysphagia after resection of oral cancer, it has been noted not only the muscle tissue loss to affect the dysfunction of muscles around the focus. Tongue cancer in the surrounding normal muscle has made it clear that changing the type of slow twitch muscles to grow in the process of healing injured or regeneration.
Moreover, the distribution of High Mobility Group 1 used as a tumor marker was retrieved. Then, it has been understood that HMGB1 appears to not only the tumor cell but also the reproduction muscle.
This means that the muscle fiber around oral cancer has changed with weak muscle contraction configuration. It was occupied by the regeneration of the muscle revealed that the muscle dysfunction caused.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (9 results)

All 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Expression of HGF and IGF-1 during regeneration of masseter muscle in mdx mice.2010

    • Author(s)
      Honda H, Abe S, Ishida R, Watanabe Y, Iwanuma O, Sakiyama K, Ide Y.
    • Journal Title

      J Muscle Res Cell Motil 32

      Pages: 71-77

    • Related Report
      2010 Final Research Report
  • [Journal Article] Expression of HGF and IGF-1 during regeneration of masseter muscle in mdx mice.2010

    • Author(s)
      Honda H, Abe S, Ishida R, Watanabe Y, Iwanuma O, Sakiyama K, Ide Y.
    • Journal Title

      J Muscle Res Cell Motil

      Volume: 32 Pages: 71-77

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of mechanical stretching on expressions of muscle specific transcription factors MyoD, Myf-5, myogenin and MRF4 in proliferated myoblasts.2009

    • Author(s)
      Abe S, Rhee S, Iwanuma O, Hiroki E, Yanagisawa N, Sakiyama K, Ide Y.
    • Journal Title

      Anat Histol Embryol 38

      Pages: 305-310

    • Related Report
      2010 Final Research Report
  • [Journal Article] Effect of mechanical stretching on expressions of muscle specific transcription factors MyoD, Myf-5, myogenin and MRF4 in proliferated myoblasts.2009

    • Author(s)
      Abe S
    • Journal Title

      Anat Histol Embryol 38

      Pages: 305-310

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 舌癌が周囲筋線維に与える影響2009

    • Author(s)
      崎山浩司、井上勝元、土居孝資、佐々木会、岩沼治、天野修
    • Organizer
      第51回歯科基礎医学会総会・学術大会
    • Place of Presentation
      新潟市
    • Year and Date
      2009-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 舌癌が周囲筋線維に与える影響2009

    • Author(s)
      崎山浩司
    • Organizer
      第51回歯科基礎医学会総会・学術大会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] マウス舌癌周囲筋組織の筋線維特性2009

    • Author(s)
      崎山浩司、井上勝元、岩沼治、阿部伸一、井出吉信、天野修
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山市
    • Year and Date
      2009-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] マウス舌癌周囲筋組織の筋線維特性2009

    • Author(s)
      崎山浩司
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山理科大学
    • Year and Date
      2009-03-30
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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