Astroglia in medullary dorsal horn are involved in trigeminal neuropathic pain mechanisms.

• Project/Area Number: 20791552
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Nihon University
• Principal Investigator: OKADA Akiko Nihon University, 歯学部, 専任講師 (10434078)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 歯学 / 神経科学 / 生理学 / 脳・神経 / 細胞・組織

Research Abstract

The present findings suggest that astroglia are invoIvedin the enhanced excitability of medullary dorsal horn (MDH) nociceptive neurons and the associated referred pain in the superior maxillarynerve area from inferior alveolar nerve inJury.

Research Products

• [Journal Article] A possible case of complex regional pain syndrome in the orofacial region (2010)
  • Author(s): Okada-Ogawa A, ImamuraY, (他7名, 4番目)
  • Journal Title: Pain Med 11 Pages: 274-280
  • Peer Reviewed
• [Journal Article] 口腔領域におけるペインコントロールの臨床-1. 口腔顔面痛の分類と概説 (2010)
  • Author(s): 岡田明子
  • Journal Title: 歯科医療冬号
• [Journal Article] 口腔顔面痛の分類と概説 (2010)
  • Author(s): 岡田明子
  • Journal Title: 歯科医療2010年冬号 24(1) Pages: 4-9
• [Journal Article] Astroglia in Medullary Dorsal Horn (Trigeminal Spinal Subnucleus Caudalis) Are Involved in Trigeminal Neuropathic Pain Mechanisms. (2009)
  • Author(s): Okada-Ogawa A, Suzuki I, Imamura Y, (他10名, 1番目)
  • Journal Title: J Neurosci. 29 Pages: 11161-11171
  • Peer Reviewed
• [Journal Article] Sustained morphine-induced sensitization and loss of diffuse noxious inhibitory controls in dura-sensitive medullary dorsal horn neurons (2009)
  • Author(s): Okada-Ogawa A, Porreca F, Meng ID.
  • Journal Title: J Neurosci. 29 Pages: 15828-15835
  • Peer Reviewed
• [Journal Article] Differential effects of the cannabinoid receptor agonist, WIN 55, 212-2, on lamina I and lamina V spinal trigeminal nucleus caudalis neurons (2009)
  • Author(s): Ogawa A, Meng ID
  • Journal Title: Pain 14 Pages: 269-275
  • Peer Reviewed
• [Journal Article] Sustained morphine-induced sensitization and loss of diffuse noxious inhibitory controls in dura-sensitive medullary dorsal horn neurons. (2009)
  • Author(s): Okada-Ogawa A.
  • Journal Title: Journal of Neuroscience 29(50) Pages: 15828-15835
  • Peer Reviewed
• [Journal Article] Astroglia in medullary dorsal horn (trigeminal spinal subnucleus caudalis) are involved in trigeminal neuropathic pain mechanisms. (2009)
  • Author(s): Okada-Ogawa A.
  • Journal Title: Journal of Neuroscience 29(36) Pages: 11161-11171
  • Peer Reviewed
• [Journal Article] Differential effects of the cannabinoid receptor agonist, WIN 55, 212-2, on lamina I and lamina V spinal trigeminal nucleus caudalis neurons (2009)
  • Author(s): Ogawa A.(旧性)
  • Journal Title: Pain 141(3) Pages: 269-275
  • Peer Reviewed
• [Journal Article] 歯・顎・口腔外科疾患による頭痛 (2008)
  • Author(s): 小川明子
  • Journal Title: 小児内科 40 Pages: 909-911
  • Peer Reviewed
• [Presentation] 片頭痛モデルラットの光刺激により三叉神経脊髄路核に発現するpERK陽性細胞の分布 (2009)
  • Author(s): 小川明子
  • Organizer: 第30回日本疼痛学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-07-09
• [Presentation] 筋圧痛と筋硬度を用いた咀嚼筋筋膜痛の検討 (2008)
  • Author(s): 岡田明子
  • Organizer: 第21回日本口腔診断学会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-18
• [Presentation] ラット下歯槽神経切断による神経因性疼痛に対するアストログリアの関与 (2008)
  • Author(s): 小川明子, 鈴木郁子, 今村佳樹, 岩田幸一
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
• [Presentation] pERK in upper cervical spinal cord neurons following photic stimulation in rats' model with migraine (2008)
  • Author(s): Akiko Ogawa
  • Organizer: 12th International Association for the Study of Pain
  • Place of Presentation: Scotland Glasgow
• [Book] 痔痛治療(スタンダード全身管理・歯科麻酔-14章ペインクリニック) (2008)
  • Author(s): 今村佳樹, 小川明子, 他
• [Book] 高齢者歯科医療-IV.高齢者に多い口腔症状とその対応.疼痛性疾患 (2008)
  • Author(s): 今村佳樹、小川明子
  • Total Pages: 5
  • Publisher: 永末書店