The effect of manners of administration and timing of sevoflurane on myocardial ischemia/reperfusion injury.

Research Project

Project/Area Number	20791554
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Kanagawa Dental College
Principal Investigator	FURUYA Munetaka Kanagawa Dental College, 歯学部, 講師 (90318890)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	セボフルレン / 心筋虚血再灌流障害 / 8-OHdG・ / 心筋保護 / 8-OHdG
Research Abstract	【2008】We compared 3.9% sevoflurane exposure groups in six different manners of administration with control group. There were no significant differences in duration of arrhythmias during myocardial ischemia and reperfusion and I/R (infarct size /area at risk) among seven groups. Although we measured 8-OHdG・in the blood, we could not detect it. 【2009】We compared continuous sevoflurane exposure groups in four different concentrations (0.5 %, 1.0%, 1.5%, 2.0%) under k/x anesthesia with control group. I/R (infarct size /area at risk) was reduced in a 1.0% sevoflurane exposure group. 1.0% continuous sevoflurane exposure depressed production of 8-OHdG^・.