The relationship of MMPs and growth factors in the invasion mechanism of adenoid cystic carcinoma

• Project/Area Number: 20791561
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Hyogo College of Medicine
• Principal Investigator: TANAKA Noriaki Hyogo College of Medicine, 医学部, 助教 (70412012)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 腺様嚢胞癌 / 3次元培養 / 浸潤機構 / MMPs / 増殖因子

Research Abstract

Adenoid cystic carcinoma is a malignant salivary gland tumor characterized by perineural and perivascular invasion. In this study, we found that MMP9 and MMP14 were associated with the invasion mechanism of adenoid cystic carcinoma. In addition, the expression of VEGF was found in the adenoid cystic carcinoma cells, and it was suggested that VEGF induced angiogenesis at peritumoral stroma. Furthermore, it might be thought that semaphorins, which were known as the neuron guidance factor, were associated with the invasion mechanism of adenoid cystic carcinoma.

Research Products

• [Journal Article] histological patterns, and metastatic potential in adenoid cystic carcinoma of head and neck (2008)
  • Author(s): Zushi Y, Noguchi K, Hashitani S, Sakurai K, Segawa E, Takaoka K, Toyohara Y, Tanaka N, Kishimoto H, Urade M
  • Journal Title: CXCR4 vol.33 Pages: 1133-1139
  • Peer Reviewed
• [Journal Article] Relations among expression of CXCR4, histological patterns, and metastatic potential in adenoid cystic carcinoma of head and neck (2008)
  • Author(s): Zushi Y, Noguchi K, Hashitani S, Sakurai K, Segawa E, Takaoka K, Toyohara Y, Tanaka N, Kishimoto H, Urade M
  • Journal Title: Int. J Oncol. 33 Pages: 1133-1139
  • Peer Reviewed
• [Presentation] Establishment of a novel adenoid cystic carcinoma cell line in the salivary gland (2008)
  • Author(s): Tanaka N
  • Organizer: Zion in University of California San Francisco
  • Place of Presentation: San Francisco
  • Year and Date: 2008-05-27