| Project/Area Number |
20791572
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
MURAKAMI Jumpei Osaka University, 歯学部附属病院, 助教 (70362689)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ダウン症候群 / 歯肉上皮細胞 / 歯周炎 / Porphyromonas gingivlais / TLR / サイトカイン / LPS / Porhromonas gingivalis / Porphyromonas gingivalis / Porvhvromohas gingivalis / インテグリン / 創傷治癒 / SV40 largeT抗原 / パキシリン |
|---|
| Research Abstract |
The long-term culture possibility stock of the gingival epithelial cell derived from the Down syndrome that had difficulty with culture conventionally was manufactured in this study. The expression of Toll-like receptor (TLR) in the Down syndrome gingival epithelial cells and the cytokines production were clarified. By P.gingivalis LPS, the expression of TLR2 and inflammatory cytokine, IL-6 and -8, was significantly promoted. In addition, it was suggested that cytokines production through TLR mainly causes the periodontitis in persons with Down syndrome because the cytokine production was decreased by TLR inhibition.
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