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An investigation of host factor associated with early onset periodontitis in persons with Down syndrome.

Research Project

Project/Area Number 20791572
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionOsaka University

Principal Investigator

MURAKAMI Jumpei  Osaka University, 歯学部附属病院, 助教 (70362689)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsダウン症候群 / 歯肉上皮細胞 / 歯周炎 / Porphyromonas gingivlais / TLR / サイトカイン / LPS / Porhromonas gingivalis / Porphyromonas gingivalis / Porvhvromohas gingivalis / インテグリン / 創傷治癒 / SV40 largeT抗原 / パキシリン
Research Abstract

The long-term culture possibility stock of the gingival epithelial cell derived from the Down syndrome that had difficulty with culture conventionally was manufactured in this study. The expression of Toll-like receptor (TLR) in the Down syndrome gingival epithelial cells and the cytokines production were clarified. By P.gingivalis LPS, the expression of TLR2 and inflammatory cytokine, IL-6 and -8, was significantly promoted. In addition, it was suggested that cytokines production through TLR mainly causes the periodontitis in persons with Down syndrome because the cytokine production was decreased by TLR inhibition.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (26 results)

All 2011 2010 2009 2008 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (14 results) Book (3 results) Remarks (1 results)

  • [Journal Article] 永久歯20本を2週2度にわたり自己抜歯した知的障害者の1例2011

    • Author(s)
      松木響子, 秋山茂久, 福留麗美, 高田勇之介, 村上旬平, 森崎市治郎
    • Journal Title

      障害者歯科

      Volume: 32 Pages: 44-48

    • NAID

      10027867633

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular and biological characterization of gtf regulation-associated genes in Streptococcus mutans.2009

    • Author(s)
      Terao Y, Isoda R, Murakami J, Hamada S, Kawabata S.
    • Journal Title

      Oral Microbiology Immunology 24

      Pages: 211-217

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extensive dental caries in unerupted permanent teeth of a disabled child with phenytoin-induced gingival overgrowth.2008

    • Author(s)
      Murakami J, Morisaki I, Ochiai.TT, Akiyama S, Amano A, Friedman CS.
    • Journal Title

      J Disability and Oral Health 9

      Pages: 13-16

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cellular motility of Down syndrome gingival fibroblasts is susceptible to impairment by Porphyromonas gingivalis invasion.2008

    • Author(s)
      Murakami J, Kato T, Kawai S, Akiyama S, Amano A, Morisaki I.
    • Journal Title

      J Periodontol 79

      Pages: 721-727

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behavior guidance in dentistry for patients with autism spectrum disorder using a structured visual guide.2008

    • Author(s)
      Morisaki I, Ochiai TT, Akiyama S, Murakami J, Friedmann CS.
    • Journal Title

      J Disability and Oral Health 9

      Pages: 136-140

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Etiologic factors of early-onset periodontal disease in Down syndrome2008

    • Author(s)
      Amano A, Murakami J, Akiyama S. Morisaki I
    • Journal Title

      Japanese Dental Science Review 44

      Pages: 118-127

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular motility of Down syndrome gingival fibroblasts is susceptible to impairment by Porphyromonas gingivasi invasion2008

    • Author(s)
      Murakami J, Kato T, Kawai S, Akiyama S, Amano A, Mofisaki I.
    • Journal Title

      J Periodontol 79

      Pages: 721-727

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extensive dental caries in unerupted permanent teeth of a disabled child with phenytoin-induced gingival overgrowth2008

    • Author(s)
      Murakami J, Morisaki I, Ochiai. TT, Akiyama S, Amano A. Friedman CS
    • Journal Title

      J Disability and Oral Health 9

      Pages: 13-16

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Rett症候群の5例2010

    • Author(s)
      堤香奈子,村上旬平, 福留麗実, 松木響子, 稲田朱美, 藤川順司, 秋山茂久, 森崎市治郎
    • Organizer
      第27回日本障害者歯科学会総会および学術大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] ダウン症候群由来歯肉上皮細胞におけるLPS刺激によるIL-6およびIL-8の発現2010

    • Author(s)
      村上旬平, 田中健司, 堤香奈子, 財間達也, 天野敦雄, 森崎市治郎
    • Organizer
      第27回日本障害者歯科学会総会および学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-23
    • Related Report
      2010 Final Research Report
  • [Presentation] ダウン症候群由来歯肉上皮細胞におけるLPS刺激によるIL-6およびIL-8の発現2010

    • Author(s)
      村上旬平、田中健司、堤香奈子、財間達也、天野敦雄、森崎市治郎
    • Organizer
      第27回日本障害者歯科学会総会および学術大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 先天性無痛無汗症児童における現在歯の実態調査2010

    • Author(s)
      秋山茂久, 東村有紀, 財間達也, 藤代千晶, 村上旬平, 池田正一, 久保寺友子, 森崎布治郎
    • Organizer
      第27回日本障害者歯科学会総会および学術大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] A case of Sturge-Weber syndrome with bilateral haemangioma and bimaxillary deformity2010

    • Author(s)
      Tsutsumi K, Tanaka K, Murakami J, Akiyama S, Morisaki I
    • Organizer
      20th congress of the International Association of Disability and Oral Health
    • Place of Presentation
      ゲント(ベルギー)
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of recent increase in special needs patients treated under general anaesthesis at Special Dental Care Unit of Osaka University Dental Hospital2010

    • Author(s)
      Tanaka K, Murakami J, Tsutsumi K, Akiyama S, Morisaki I
    • Organizer
      20th congress of the International Association of Disability and Oral Health
    • Place of Presentation
      ゲント(ベルギー)
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of removal oral appliances holding suction catheters on respiratory function for patients with severe developmental disabilities2010

    • Author(s)
      Matsuki K, Murakami J.Tanaka K, Akiyama S, Morisaki I
    • Organizer
      2010 spring congress of Korean Association for Disability and Oral Health,
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2010-05-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] ダウン症候群由来歯肉上皮細胞におけるToll-like receptor2の発現2009

    • Author(s)
      村上旬平, 竹内洋輝, 堤香奈子, 秋山茂久, 天野敦雄, 森崎市治郎
    • Organizer
      第26回日本障害者歯科学会総会および学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Porphyromonas gingivalisの細胞内動態の解析2009

    • Author(s)
      竹内洋輝, 加藤隆大, 稲葉裕明, 村上旬平, 秋山茂久, 森崎市治郎, 天野敦雄
    • Organizer
      第26回日本障害者歯科学会総会および学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-11-01
    • Related Report
      2010 Final Research Report
  • [Presentation] ダウン症候群由来歯肉上皮細胞におけるToll-like receptor2の発現2009

    • Author(s)
      村上旬平, 竹内洋輝, 堤香奈子, 秋山茂久, 天野敦雄, 森崎市治郎
    • Organizer
      第26回日本障害者歯科学会総会および学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Porphyromonas gingivalisの細胞内動態の解析2009

    • Author(s)
      竹内洋輝, 加藤隆大, 稲葉裕明, 村上旬平, 秋山茂久, 森崎市治郎, 天野敦雄
    • Organizer
      第26回日本障害者歯科学会総会および学術大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Streptococcus mutansバイオフィルム形成における酸化チタン光触媒の役割2008

    • Author(s)
      村上旬平, 福留麗実, 和田精久, 秋山茂久, 森崎市治郎
    • Organizer
      第27回日本小児歯科学会近畿地方大会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-19
    • Related Report
      2010 Final Research Report
  • [Presentation] ダウン症候群歯肉上皮細胞のSV40 largeT抗原導入による長期培養可能株の作製2008

    • Author(s)
      村上旬平, 木村敬次リチャード, 堤香奈子, 竹内洋輝, 天野敦雄, 秋山茂久, 森崎市治郎
    • Organizer
      第25回日本障害者歯科学会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-10
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] Phenytoin-induced gingival overgrowth : relationship among clinical feature, periodontal bacteria and drug metabolizing elizyme2008

    • Author(s)
      Akiyama S. Morisaki, I Murakami J.
    • Organizer
      19th congress of the International Association of Disability and Oral Health
    • Place of Presentation
      Santos/SP, Brazil
    • Related Report
      2008 Annual Research Report
  • [Book] スペシャルニーズデンティストリー障害者歯科(日本障害者歯科学会編)2009

    • Author(s)
      村上旬平
    • Total Pages
      397
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2010 Final Research Report
  • [Book] スペシャルニーズデンティストリー障害者歯科2009

    • Author(s)
      森崎市治郎, ほか
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2009 Annual Research Report
  • [Book] 生命歯科医学のカッティング・エッジ(米田俊之編)2008

    • Author(s)
      村上旬平
    • Total Pages
      289
    • Publisher
      大阪大学出版会
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.dent.osaka-u.ac.jp/~disabl/research/archives.htm

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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