Research that clarify the mechanism of cleft palate disease, and aim to development of tissue engineering treatment for palatal tissue.

• Project/Area Number: 20791581
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Nihon University
• Principal Investigator: OKA Kyoko Nihon University, 歯学部, 助教 (60452778)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 神経堤細胞 / 口蓋裂 / TGF-bシグナル / 軟口蓋発生 / TGF-b / 器官培養 / 口蓋発生 / 中胚葉由来細胞

Research Abstract

The results of analysis for localization of cranial neural crest cells (CNC) in palatal tissue by using Wnt1-cre ; R26R mice, not only hard palate also soft palate was composed by CNC. During development of soft palate, palatine aponeurosis is organized by CNC cells expressing Col I mRNA. TGF-b signaling controls the proliferation of palatal mesenchymal cells and induces Col I protein deposition.

Research Products

• [Journal Article] The role of TGF-βsiginaling in cranial neural crest cells during mandibular and tooth development. (2009)
  • Author(s): Oka K, Oka S, Cai Y.
  • Journal Title: J Oral Biosci. 51(3)(Review) Pages: 143-150
  • Peer Reviewed
• [Journal Article] The role of TGF-β signaling in cranial neural crest cells during mandibular and tooth development (2009)
  • Author(s): Kyoko OKA
  • Journal Title: J.Oral Biosci. 51(3) Pages: 143-150
  • Peer Reviewed
• [Journal Article] Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression (2008)
  • Author(s): Yamamoto S
  • Journal Title: Journal of Biochemistry 22 Pages: 23139-23149
  • Peer Reviewed
• [Presentation] マウス軟口蓋・口蓋腱膜形成におけるTGF-bシグナルの役割 (2010)
  • Author(s): 岡暁子
  • Organizer: 第115回日本解剖学会総会
  • Place of Presentation: 岩手県盛岡市県民会館
  • Year and Date: 2010-03-30
• [Presentation] マウス軟口蓋・口蓋腱膜形成におけるTGF-βシグナルの役割 (2010)
  • Author(s): 岡暁子
  • Organizer: 第115回 日本解剖学会総会
  • Place of Presentation: 岩手県盛岡市 県民会館
  • Year and Date: 2010-03-30
• [Presentation] 口蓋発生におけるTGF-bシグナルの役割 (2008)
  • Author(s): 岡暁子
  • Organizer: 第46回日本小児歯科学会大会
  • Place of Presentation: さいたま市大宮区
  • Year and Date: 2008-06-12
• [Presentation] 口蓋発生におけるTGF-βシグナルの役割 (2008)
  • Author(s): 岡暁子
  • Organizer: 第46回日本小児歯科学会大会
  • Place of Presentation: さいたま市大宮区
  • Year and Date: 2008-06-12