Analysis of regulatory mechanisms of odontoblast differentiationby novel gap junction protein
| Project/Area Number |
20791583
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
IWAMOTO Tsutomu Kyushu University, 病院, 助教 (90346916)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 歯胚発生 / 象牙芽細胞 / マトリックス蛋白 / 細胞間蛋白 / 歯胚形成 / 細胞間結合 / TI-3 |
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| Research Abstract |
To find genes, important for tooth development, we had generated tooth cDNA library, and have been trying to find novel and functional genes. So far, we have identified a novel matrix protein gene, named TM14/Fibluin7. We found that TM14/Fibluin 7 has an important role for odontoblast attachment. And also, we have identified a hard tissue specific novel gap junction gene, and have been analyzing its function in tooth, cartilage and bone development.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] The critical role of heparin binding domains of ameloblastin for dental epithelium cell adhesion and ameloblastoma proliferation.2009
Author(s)
Sonoda A*, Iwamoto T*, Nakamura T, Fukumoto E, Yoshizaki K, Yamada A, Arakaki M, Harada H, Nonaka K, Nakamura S, Yamada Y, Fukumoto S.
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Journal Title
J Biol Chem 284(40)
Pages: 27176-84
Related Report
Peer Reviewed
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