| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
To analyze the neural regulation of the bone metabolism under the mechanical stress, we investigated the role of osteoactivin (OA) in the human periodontal ligament (HPDL) cells. When the mechanical stress was loaded to the rat molar, OA appeared in the HPDL cells, osteoblasts, and osteoclasts. When HPDL cells were given the tension force, the immunoreactivity of OA was reduced. These results suggested that tension forces induced the release of extracellular domain of OA, resulting in the stimulation of bone formation at the tension side.
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