Analysis of the neural regulation of the bone metabolism under the mechanical stress.
Project/Area Number |
20791586
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Orthodontic/Pediatric dentistry
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Research Institution | Kyushu Dental College |
Principal Investigator |
KUROISHI Kayoko Kyushu Dental College, 歯学科, 助教 (60468303)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | メカニカルストレス / 神経 / 歯根膜線維芽細胞 / オステオアクチビン / 骨形成 / 骨代謝 / 神経ペプチド / 骨芽細胞 / 破骨細胞 / 免疫染色 / 歯学 / ストレス |
Research Abstract |
To analyze the neural regulation of the bone metabolism under the mechanical stress, we investigated the role of osteoactivin (OA) in the human periodontal ligament (HPDL) cells. When the mechanical stress was loaded to the rat molar, OA appeared in the HPDL cells, osteoblasts, and osteoclasts. When HPDL cells were given the tension force, the immunoreactivity of OA was reduced. These results suggested that tension forces induced the release of extracellular domain of OA, resulting in the stimulation of bone formation at the tension side.
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Report
(4 results)
Research Products
(20 results)