| Project/Area Number |
20791587
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
OKAYAMA Miki Health Sciences University of Hokkaido, 歯学部, 助教 (30382500)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | メカニカルストレス / 歯の移動 / 歯周組織 / 歯根膜細胞 / リン酸化 / プリン受容体 |
|---|
| Research Abstract |
Gravity loading (G-loading) was applied to human periodontal ligament (PDL) as a model of mechanical stress. ERK was phosphorylated after 5 min by G-loading at 7G and the phosphorylation of ERK was observed with ATP treatment to the cells at 5 min. G-loading also induced ATP in PDL. An inhibitor of purenargic receptor diminished ERK phosphorylation by G-loading and UTP, P2Y specific agonist induced ERK phosphoryaltion. Thus, G-loading induced ERK phophrylation via ATP and P2Y receptor.
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