| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Mouse amelotin gene was over-expressed in mouse osteoblatsic cell line and osteoblastic differentiation was induced. We observed enhanced mineralized nodule formation, whereas osteoblastic differentiation marker gene expressions were not changed. In immuno-electron microscopic observation, we also found the tendency of amelotin to bind to calcium and phosphate when the cells were stimulated to form mineralized nodule. These data suggested the capacity of amelotin to enhance bone formation and possibility of its application for periodontal regeneration.
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