Mechanism of periodontal tissue destruction caused by Th17 axis.

Research Project

Project/Area Number	20791608
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Periodontal dentistry
Research Institution	Tokyo Medical and Dental University
Principal Investigator	KOBAYASHI Hiroaki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (50396967)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	歯周免疫機能学 / 歯周炎 / Th17 / IL-23 / 歯周病原細菌
Research Abstract	Periodontitis is an inflammatory disease caused by periodontopathic bacteria. The aim of this study was to clarify whether IL-23 production is correlated with periodontal tissue destruction. But, there was no correlation between IL-23 production from periodontitis patients monocytes and clinical parameters. As the severity of periodontitis was not correlated with IL-23 production, individual diversity in IL-23 might not affect the susceptibility of periodontitis directly.

Report

(3 results)