The development of drug for alveolar bone regeneration targeting the Wnt signaling pathway

• Project/Area Number: 20791616
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Kyushu University
• Principal Investigator: MATSUZAKI Etsuko Kyushu University, 大学病院, 助教 (20432924)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 骨芽細胞 / Wntシグナル / 再生医学 / anti-Dkk1抗体 / 骨再生

Research Abstract

Dkk1 is an inhibitor of Wnt signaling and inhibits bone formation. Recent studies show that anti-Dkk1 antibody is useful for the osteolytic disease including multiple myeloma and rheumatoid arthritis. We found that anti-Dkkl antibody induced osteoblast differentiation and calcification.

Research Products

• [Presentation] 骨再生を目指したWntシグナル伝達経路活性化薬の可能性 (2009)
  • Author(s): 松崎英津子, 他
  • Organizer: 第30回日本臨床薬理学会年会シンポジウム
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
  • Year and Date: 2009-12-03
• [Presentation] 骨再生を目指したWntシグナル伝達経路活性化薬の可能性 (2009)
  • Author(s): 松崎英津子
  • Organizer: 第30回日本臨床薬理学会年会 シンポジウム
  • Place of Presentation: 神奈川県横浜市、パシフィコ横浜
  • Year and Date: 2009-12-03
• [Presentation] The effect of anti-Dkkl antibody on the Wnt/beta-catenin signaling pathway (2009)
  • Author(s): 小林茉莉、松崎英津子, 他
  • Organizer: The 11th Joint-Scientific Meeting between Japanese Society of Conservative Dentistry and Korean Academy of Conservative Dentistry
  • Place of Presentation: Ramada Plaza, Jeju, Korea
  • Year and Date: 2009-11-13
• [Presentation] The effect of anti-Dkk1 antibody on the Wnt/β-catenin signaling pathway (2009)
  • Author(s): 小林茉莉
  • Organizer: The 11th Joint-Scientific Meeting between Japanese Society of Conservative Dentistry and Korean Academy of Conservative Dentistry
  • Place of Presentation: Ramada Plaza, Jeju, Korea
  • Year and Date: 2009-11-13
• [Presentation] 抗Dkk1抗体がWnt/ β-カテニンシグナルを介して骨芽細胞分化におよぼす影響 (2009)
  • Author(s): 小林茉莉、松崎英津子, 他
  • Organizer: 第52回秋季日本歯周病学会学術大会
  • Place of Presentation: 宮崎県宮崎市宮崎観光ホテル
  • Year and Date: 2009-10-11
• [Presentation] 抗Dkk1抗体がWnt/β-カテニンシグナルを介して骨芽細胞分化におよぼす影響 (2009)
  • Author(s): 小林茉莉
  • Organizer: 第52回秋季日本歯周病学会学術大会
  • Place of Presentation: 宮崎県宮崎市、宮崎観光ホテル
  • Year and Date: 2009-10-11
• [Presentation] Wnt signaling and osteoblast differentiation (2009)
  • Author(s): 松崎英津子, 他
  • Organizer: The 4th International Symposium for Dental and CraniOfacial Morphogenesis and Tissue RegeneratiOn
  • Place of Presentation: 九州大学、百年講堂
  • Year and Date: 2009-02-06
• [Presentation] Wnt signaling and osteoblast differentiation (2009)
  • Author(s): 松崎英津子(代表)
  • Organizer: The 4th International Symposium for Dental and Craniofacial Morphogeesis and Tissue Regeneration
  • Place of Presentation: 九州大学、百年講堂
  • Year and Date: 2009-02-06
• [Presentation] Wnt signaling and osteoblast differentiation (2008)
  • Author(s): 松崎英津子, 他
  • Organizer: The 10th Joint-Scientific Meeting between Japanese Society of Conservative Dentistry and Korean Academy of Conservative Dentistry
  • Place of Presentation: COEX conventional center, Seoul, Korea
  • Year and Date: 2008-11-28
• [Presentation] Wnt signaling and osteoblast differentiation (2008)
  • Author(s): 松崎英津子(代表)
  • Organizer: 10th Joint-Scientific Meeting between Japanese Society of Conservative Dentistry and Korean Academy of Conservative Dentistry
  • Place of Presentation: COEX conventional center, Seoul, Korea
  • Year and Date: 2008-11-28
• [Book] 臨床薬理 (2010)
  • Author(s): 松崎英津子, 他
  • Publisher: 三原医学社
• [Book] 臨床薬理Vol.41, No.2 (2010)
  • Author(s): 松崎英津子
  • Publisher: 三原医学社(印刷中)