Molecular biological analysis of periodontitis and metabolic syndrome based on renin-angiotenshin system

Research Project

Project/Area Number	20791618
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Periodontal dentistry
Research Institution	Kagoshima University
Principal Investigator	NAKAMURA Toshiaki Kagoshima University, 大学院・医歯学総合研究科, 助教 (60381183)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	歯周病 / 歯肉 / メタボリックシンドローム / アンジオテンシン / RAS / 歯学 / Angiotensin / メタボリック
Research Abstract	The aim of the present study was to investigate the expression of renin-angiotensin system (RAS) components, which has been considered to be concerned with several steps of metabolic syndrome, in human gingival tissues and the effects of RAS on inflammatory reactions in cultured human gingival fibroblasts (HGF). This study demonstrated that tissue RAS exists in HGT and IL-6 induced by IL-1β may be partially regulated through AT1R in HGF. These facts suggest that RAS may be involved in the regulation of inflammatory responses in periodontal disease.

Report

(3 results)