Analysis of interspecies communication in oral biofilms

• Project/Area Number: 20791621
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: INAGAKI Satoru Tokyo Dental College, 歯学部, 助教 (20385165)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: Treponema denticola / バイオフィルム / 口腔細菌 / 細胞侵入 / 定着抑制 / T.denticola

Research Abstract

During dental plaque formation, the interaction of different organisms is important in the development of complex communities. We analyzed the bacterial virulence which promotes biofilm formation and cellular invasion.

Research Products

• [Journal Article] Differential ability of periodontopathic bacteria to modulate invasion of human gingival epithelial cells by Porphyromonas gingivalis. (2009)
  • Author(s): Saito A, Inagaki S, Ishihara K
  • Journal Title: Microb Pathog. 47(6) Pages: 329-33
  • Peer Reviewed
• [Journal Article] The OxyR homologue in Tannerella forsythia regulates expression of oxidative stress responses and biofilm formation. (2009)
  • Author(s): Honma K, Inagaki S, Sharma A, 他1名3番目
  • Journal Title: Microbiology 155(6) Pages: 1912-22
  • Peer Reviewed
• [Journal Article] Differential ability of periodontopathic bacteria to modulate invasion of human gingival epithelial cells by Porphyromonas gingivali. (2009)
  • Author(s): Saito A, Inagaki S, et al
  • Journal Title: Microb Pathog 47 Pages: 329-333
  • Peer Reviewed
• [Journal Article] The OxyR homologue in Tannerella forsythia regulates expression of oxidative stress responses and biofilm formation (2009)
  • Author(s): Honma K, Inagaki S, et al
  • Journal Title: Microbiology 155 Pages: 1912-1922
  • Peer Reviewed
• [Journal Article] Fusobacterium nucleatum enhances invasion of human gingival epithelial and aortic endothelial cells by Porphyromonas gingivalis. (2008)
  • Author(s): Saito A, Inagaki S, Ishihara K, 他3名2番目
  • Journal Title: FEMS Immunol Med Microbiol. 54(3) Pages: 394-55
  • Peer Reviewed
• [Journal Article] Fusobacterium nucleatum enhances invasion of human gingival epithelial and aortic endothelial cells by Porphyromonas gingivalis (2008)
  • Author(s): Saito S, Inagaki S, et.al.
  • Journal Title: FEMS Immunol Med Microbiol 54(3) Pages: 394-55
  • Peer Reviewed
• [Presentation] 誘電泳動インピーダンス計測法を用いた迅速微生物数測定装置による口腔微生物の測定評価 (2010)
  • Author(s): 稲垣覚
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: 横浜市(パシフィコ横浜)
  • Year and Date: 2010-03-27
• [Presentation] 歯周病原菌Treponema denticolaのヒト歯肉上皮細胞への侵入 (2009)
  • Author(s): 稲垣覚
  • Organizer: 第92回日本細菌学会関東支部総会
  • Place of Presentation: 東京(東京医科歯科大)
  • Year and Date: 2009-11-05
• [Presentation] 歯周病原菌Treponema denticolaのヒト歯肉上皮細胞への侵入 (2009)
  • Author(s): 稲垣覚
  • Organizer: 第51回歯科基礎医学会学術大会
  • Place of Presentation: 新潟市(朱鷺メッセ)
  • Year and Date: 2009-09-10
• [Presentation] 歯周病原菌Treponema denticolaのヒト歯肉上皮細胞への侵入 (2009)
  • Author(s): 稲垣覚、齋藤淳、君塚隆太、石原和幸
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2009-03-12
• [Presentation] 歯周病原菌Treponema denticolaのヒト歯肉上皮細胞への侵入 (2009)
  • Author(s): 稲垣覚齋藤淳、君塚隆太、石原和幸
  • Organizer: 第51回歯科基礎医学会学術大会・総会
  • Place of Presentation: 朱鷺メッセ(新潟市)
• [Presentation] 歯周病原菌Treponema denticolaのヒト歯肉上皮細胞への侵入 (2009)
  • Author(s): 稲垣覚齋藤淳、君塚隆太、石原和幸
  • Organizer: 第92回日本細菌学会関東支部総会
  • Place of Presentation: 東京医科歯科大学(東京)
• [Presentation] Invasion of host cells by periodontopathic bacteria in polymycrobial infection (2009)
  • Author(s): A. SAITO, S. INAGAKI, R. KIMIZUKA, K. ISHIHARA
  • Organizer: IADR 87th General Session & Exhibition
  • Place of Presentation: Miami
• [Presentation] 歯周病原菌Treponema denticolaのヒト歯肉上皮細胞への侵入 (2009)
  • Author(s): 稲垣覚, 齋藤淳, 君塚隆太, 石原和幸
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
• [Presentation] 生命の森リゾート日本エアロビクスセンター(長柄町)歯周病原菌Treponema denticolaのヒト歯肉上皮細胞への侵入 (2008)
  • Author(s): 稲垣覚齋藤淳君塚隆太石原和幸
  • Organizer: 第91回日本細菌学会関東支部総会
  • Place of Presentation: 長柄町
  • Year and Date: 2008-10-24
• [Presentation] 歯周病原菌Treponema denticolaのヒト歯肉上皮細胞への侵入 (2008)
  • Author(s): 稲垣覚、齋藤淳、君塚隆太、石原和幸
  • Organizer: 第91回日本細菌学会関東支部総会
  • Place of Presentation: 長柄町
  • Year and Date: 2008-10-24
• [Presentation] Treponema denticola dentilisin is involved in gingival epithelial cell invasion (2008)
  • Author(s): Inagaki S, Ishihara K, et.al.
  • Organizer: 第4回中日口腔医学大会
  • Place of Presentation: 西安, 中国
  • Year and Date: 2008-09-28
• [Presentation] Treponema denticola invasion of human gingival epithelial cells (2008)
  • Author(s): S. INAGAKI, R. KIMIZUKA, K. OKUDA, K. ISHIHARA
  • Organizer: IADR 86th General Session & Exhibition
  • Place of Presentation: Toronto
  • Year and Date: 2008-07-05
• [Presentation] Treponema denticola invasion of human gingival epithelial cells (2008)
  • Author(s): Inagaki S, Ishihara K, et.al.
  • Organizer: 86th IADR General Session
  • Place of Presentation: Toronto, CANADA
  • Year and Date: 2008-07-04
• [Presentation] Treponema denticola dentilisin is involved in gingival epithelial cell invasion (2008)
  • Author(s): Inagaki, S., Kimizuka, R., Ishihara, K
  • Organizer: 第4回日中歯科医学会
  • Place of Presentation: 西安