The role of anti-phosholipid antibody against periodontal pathogen to facilitate cardiovascular disease.

• Project/Area Number: 20791627
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: HISHIKAWA Toshimitsu Aichi Gakuin University, 歯学部, 非常勤講師 (10421249)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 歯周免疫機能学 / 歯周病 / 心臓血管疾患 / anti-Phospholipid / 樹状細胞 / 動脈硬化症 / anti-phospholipid / 酸化LDL

Research Abstract

oxLDL opsonized with anti-phospholipid promotes production of proinflammatory cytokines by DCs and NK cells and thus may participate in the pathogenesis of atherosclerosis. Opsonization of oxLDL by anti-phospholipid could provide a mechanism to help explain why periodontitis patients are more likely to develop atherosclerosis.