The development of genetic tests regarding cariogenicity of mutans streptococci

• Project/Area Number: 20791635
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Niigata University
• Principal Investigator: KANEKO Noboru Niigata University, 医歯学系, 助教 (00397126)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 歯学 / ミュータンスレンサ球菌 / 齲蝕原性

Research Abstract

An important virulence factor of S. mutans is a glucosyltransferase synthesizing water-insoluble glucan (WIG) from sucrose. We performed sequencing of the gtfB gene of 72 S. mutans isolates derived from primary school students.
GtfB coded by gtfB gene possess two functional domain. The carboxyl-terminal portion of GtfB is called the glucan binding domain and is coded by the direct repeating units. The results of this study indicated that the number of the repeating sequences in gtfB is associated with WIG synthesis by S.mutans

Research Products

• [Journal Article] Availability of air powder polishing with crystalline cellulose as a prophylactic method for orthodontic patients with a multi-bracket appliance. (2010)
  • Author(s): Shinzawa-Fukushima M, Kanaya T,Kaneko N, Morita S, Miyazaki H, SaitoI
  • Journal Title: Orthodontic Waves 69 Pages: 75-81
  • Peer Reviewed
• [Journal Article] 乳・幼児健診に併設し実施する間接健診および個別指導が行動変容に及ぼす影響 (2010)
  • Author(s): 葭原明弘, 金子昇, 杉本智子, 清田義和, 佐藤徹, 宮崎秀夫
  • Journal Title: 口腔衛生学会雑誌 60(1) Pages: 11-16
  • Peer Reviewed
• [Journal Article] Availability of air powder polishing with crystalline cellulose as a prophylactic method for orthodontic patients with a multi-bracket appliance (2010)
  • Author(s): Shinzawa-Fukushima M, Kanaya T, Kaneko N, Morita S, Miyazaki H, Saito I
  • Journal Title: Orthodontic Waves Volume: 69(2) Pages: 75-81
  • Peer Reviewed
• [Journal Article] Availability of air powder polishing with crystalline cellulose as a prophylactic method for orthodontic patients with a multi-bracket appliance (2010)
  • Author(s): Fukushima M, Kanaya T, Kaneko N, Morita S, Miyazaki H, Saito I
  • Journal Title: Orthodontic Waves (印刷中)
  • Peer Reviewed
• [Presentation] Glucan synthesis by Streptococcus mutans and caries incidence in schoolchildren. (2010)
  • Author(s): Kaneko N, Umetsu H, Yoshihara A,Sakuma S, Hanada N, Miyazaki H
  • Organizer: 88th General Session of the IADR
  • Place of Presentation: Barcelona(Spain)
• [Presentation] Glucan synthesis by Streptococcus mutans and caries incidence in schoolchildren (2010)
  • Author(s): Kaneko N, Umetsu H, Yoshihara A, Sakuma S, Hanada N, Miyazaki H
  • Organizer: 88th General Session of the IADR
  • Place of Presentation: Barcelona (Spain)
• [Presentation] Relationship between salivary Porphyromonas gingivalis and periodontal conditions. (2009)
  • Author(s): Naito H, Takayama K, Masuda H,Tachino A, Ishihara Y, Kaneko N, Miyazaki H
  • Organizer: 87th General Session of the IADR
  • Place of Presentation: Miami(USA)
• [Presentation] 血清および唾液中Porphyromonas gingivalis 抗体価と冠動脈性心疾患リスク因子との関連性の検討 (2009)
  • Author(s): 金子昇, 濃野要, 今井奨, 葭原明弘, 花田信弘, 宮崎秀夫
  • Organizer: 口腔衛生会誌, 59(4):496
• [Presentation] 血清および唾液中抗Porphyromonas gingivalis 抗体価と冠動脈性心疾患のリスク因子との関連 (2009)
  • Author(s): 金子昇, 花田信弘
  • Organizer: 日本細菌学雑誌, 64(1):163
• [Presentation] フッ化物洗口実施児童におけるStreptococcus mutansの非水溶性グルカン合成能とう蝕との関連 (2008)
  • Author(s): 梅津英裕, 金子昇, 葭原明弘, 佐久間汐子, 宮崎秀夫
  • Organizer: 平成20年度新潟歯学会第1回例会
  • Place of Presentation: 新潟市
  • Year and Date: 2008-07-19
• [Presentation] フッ化物洗口実施児童におけるStreptococcus mutans の非水溶性グルカン合成能とう蝕との関係 (2008)
  • Author(s): 梅津英裕, 金子昇, 葭原明弘, 佐久間汐子, 宮崎秀夫
  • Organizer: 新潟歯学会雑誌, 38(2):131-132