A Porphyromonas gingivalis tyrosine phosphatase is a multifunctional regulator of virulence attributes.

Research Project

Project/Area Number	20791638
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Social dentistry
Research Institution	Osaka University
Principal Investigator	MAEDA Kazuhiko Osaka University, 大学院・歯学研究科, 助教 (00346165)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	歯周病 / Phosphotyrosine phosphatase / バイオフィルム / Porphyromonas gingivalis口腔レンサ球菌 / LuxS / 共焦点顕微鏡 / エキソポリサッカライド / Porphyromonas gingivalis / Kgp / Rgp / 鉄 / リン酸化チロシン / Phosphtyrosing phosphatase / 口腔レンサ球菌
Research Abstract	Porphyromonas gingivalis, an opportunistic oral pathogen, expresses a Ltp1. We characterized the enzymatic activity of Ltp1 and, through the use of the mutant that lack Ltp1, showed that the activity constrains biofilm development.

Report

(3 results)