A Porphyromonas gingivalis tyrosine phosphatase is a multifunctional regulator of virulence attributes.
| Project/Area Number |
20791638
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
MAEDA Kazuhiko Osaka University, 大学院・歯学研究科, 助教 (00346165)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 歯周病 / Phosphotyrosine phosphatase / バイオフィルム / Porphyromonas gingivalis口腔レンサ球菌 / LuxS / 共焦点顕微鏡 / エキソポリサッカライド / Porphyromonas gingivalis / Kgp / Rgp / 鉄 / リン酸化チロシン / Phosphtyrosing phosphatase / 口腔レンサ球菌 |
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| Research Abstract |
Porphyromonas gingivalis, an opportunistic oral pathogen, expresses a Ltp1. We characterized the enzymatic activity of Ltp1 and, through the use of the mutant that lack Ltp1, showed that the activity constrains biofilm development.
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Report
(3 results)
Research Products
(3 results)
