| Project/Area Number |
20791642
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
TOMOFUJI Takaaki Okayama University, 岡山大学病院, 講師 (80335629)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯学 / 栄養 / トランスレーショナルリサーチ / 栄養学 |
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| Research Abstract |
Studies indicate a correlation between obesity and periodontitis. We hypothesized that increased blood oxidative stress following obesity might damage periodontal tissues. The obese Zucker rats (n= 14) and their lean littermates (n= 14) were divided into two groups of 7 rats, respectively. In one of each group, periodontitis was ligature-induced for 4 wks, while the other group was left unligated. Compared to lean Zucker rats, obese Zucker rats showed enhanced gingival 8-hydroxydeoxyguanosine levels, with increasing serum reactive oxygen metabolites. The periodontal lesion in obese rats also showed higher 8-hydroxydeoxyguanosine levels and polymorphonuclear leukocyte infiltration than the inflamed ones in lean rats, with down-regulation of multiple cytochrome P450 gene expression. These findings suggest that obesity induced gingival oxidative damage by increasing blood oxidative stress and augmented periodontal inflammation due to a reduced capacity for xenobiotic detoxification in rats.
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