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Effects of obesity on oxidative stress and periodontitis progression

Research Project

Project/Area Number 20791642
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Social dentistry
Research InstitutionOkayama University

Principal Investigator

TOMOFUJI Takaaki  Okayama University, 岡山大学病院, 講師 (80335629)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯学 / 栄養 / トランスレーショナルリサーチ / 栄養学
Research Abstract

Studies indicate a correlation between obesity and periodontitis. We hypothesized that increased blood oxidative stress following obesity might damage periodontal tissues. The obese Zucker rats (n= 14) and their lean littermates (n= 14) were divided into two groups of 7 rats, respectively. In one of each group, periodontitis was ligature-induced for 4 wks, while the other group was left unligated. Compared to lean Zucker rats, obese Zucker rats showed enhanced gingival 8-hydroxydeoxyguanosine levels, with increasing serum reactive oxygen metabolites. The periodontal lesion in obese rats also showed higher 8-hydroxydeoxyguanosine levels and polymorphonuclear leukocyte infiltration than the inflamed ones in lean rats, with down-regulation of multiple cytochrome P450 gene expression. These findings suggest that obesity induced gingival oxidative damage by increasing blood oxidative stress and augmented periodontal inflammation due to a reduced capacity for xenobiotic detoxification in rats.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (13 results)

  • [Journal Article] Effects of topical application of lipopolysaccharide and proteases on hepatic injury induced by high-cholesterol diet in rat.2010

    • Author(s)
      Yamamoto T, Tomofuji T, Tamaki N, et al.
    • Journal Title

      J Periodont Res 45

      Pages: 129135-129135

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of periodontitis on aortic insulin resistance in an obese rat model.2010

    • Author(s)
      Ekuni D, Tomofuji T, Irie K, et al.
    • Journal Title

      Lab Invest 90

      Pages: 348359-348359

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of obesity on gingival oxidative stress in a rat model2009

    • Author(s)
      Tomofuji T, Yamamoto T, Tamaki N, Ekuni D, Azuma T, Sanbe T, Irie K, Kasuyama K, Umakoshi M, Murakami J, Kokeguchi S, Morita M
    • Journal Title

      J Periodontol 80

      Pages: 1324-1329

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress2009

    • Author(s)
      Ekuni D, Tomofuji T, Sanbe T, Irie K, Azuma T, Maruyama T, Tamaki N, Murakami J, Kokeguchi S, Yamamoto T
    • Journal Title

      Arch Oral Biol 54

      Pages: 495-502

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of improvement of periodontal inflammation by toothbrushing on serum lipopolysaccharide concentration and liver injury in rats2009

    • Author(s)
      Tomofuji T, Ekuni D, Sanbe T, Azuma T, Tamaki N, Irie K, Maruyama T, Yamamoto T, Watanabe T, Miyauchi M, Takata T
    • Journal Title

      Acta Odontol Scand 67

      Pages: 200-205

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodontitis and increase in circulating oxidative stress2009

    • Author(s)
      Tomofuji T, Irie K, Sanbe T, Ekuni D, Azuma T, Tamaki N, Yamamoto T, Morita M
    • Journal Title

      Jap Dent Sci Rev 45

      Pages: 46-51

    • NAID

      10025820545

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodontitis-induced lipid peroxidation in rat descending aorta is involved in initiation of atherosclerosis2009

    • Author(s)
      Ekuni D, Tomofuji T, Sanbe T, Irie K, Azuma T, Maruyama T, Tamaki N, Murakami J, Kokeguchi S, Yamamoto T
    • Journal Title

      J Periodont Res 44

      Pages: 434-442

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin C intake inhibits serum lipid peroxidation and osteoclast differentiation on alveolar bone in rats fed on a high-cholesterol diet2009

    • Author(s)
      Sanbe T, Tomofuji T, Ekuni D, Azuma T, Irie K, Tamaki N, Yamamoto T, Morita M
    • Journal Title

      Arch Oral Biol 54

      Pages: 235-240

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of obesity on gingival oxidative stress in a rat model.2009

    • Author(s)
      Tomofuji T, Yamamoto T, Tamaki N, et al.
    • Journal Title

      J Periodontol 80

      Pages: 13241329-13241329

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of vitamin C intake on gingival oxidative stress in rat periodontitis2009

    • Author(s)
      Tomofuji T, Ekuni D, Sanbe T, et.al.
    • Journal Title

      Free Radic Biol Med 46

      Pages: 163-168

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin C intake inhibits serum lipid peroxidation and osteoclast differentiation on alveolar bone in rats fed on a high-choleserol diet2009

    • Author(s)
      Sanbe T, Tomofuji T, Ekuni D, et.al.
    • Journal Title

      Arch Oral Biol 54

      Pages: 235-240

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress2009

    • Author(s)
      Ekuni D, Tomofuji T, Sanbe T, et.al.
    • Journal Title

      Arch Oral Biol 54

      Pages: 495-502

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 酸化ストレスを介した全身と歯周状態との関係2009

    • Author(s)
      友藤孝明
    • Organizer
      第58回日本口腔衛生学会・総会
    • Place of Presentation
      岐阜
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 高コレステロール食によるラットの血清過酸化脂質の増加と歯槽骨における破骨細胞の分化:ビタミンC摂取の影響2008

    • Author(s)
      三部俊博, 友藤孝明, 江國大輔, 東哲司
    • Organizer
      第29回岡山歯学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2008-11-24
    • Related Report
      2009 Final Research Report
  • [Presentation] アンケートによる歯周疾患スクリーニングの有効性2008

    • Author(s)
      小山玲子, 玉木直文, 丸山貴之, 友藤孝明, 江國大輔, 山中玲子, 東哲司, 山本龍生, 森田学
    • Organizer
      第29回岡山歯学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2008-11-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 歯の健康に関する保健指導2008

    • Author(s)
      友藤孝明
    • Organizer
      特定検診・保健指導実践者育成研修会
    • Place of Presentation
      岡山
    • Year and Date
      2008-07-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 小学生における食習慣と咬合力・咬合接触面積の関係2008

    • Author(s)
      古田美智子, 山中玲子, Akhter Rahena, 小山玲子, 友藤孝明, 江國大輔, 玉木直文, 東哲司, 山本龍生, 岸本悦央
    • Organizer
      第19回日本口腔衛生学会近畿・中国・四国地方会総会
    • Place of Presentation
      徳島
    • Year and Date
      2008-06-22
    • Related Report
      2009 Final Research Report
  • [Presentation] アンケートによる歯周疾患スクリーニングの有効性2008

    • Author(s)
      小山玲子, 玉木直文, 丸山貴之, 友藤孝明, 江國大輔, 山中玲子, 東哲司, 山本龍生
    • Organizer
      第19回日本口腔衛生学会近畿・中国・四国地方会総会
    • Place of Presentation
      徳島
    • Year and Date
      2008-06-22
    • Related Report
      2009 Final Research Report
  • [Presentation] 歯周組織の状態と血漿の酸化ストレス度・抗酸化力との関係2008

    • Author(s)
      丸山貴之, 玉木直文, 友藤孝明, 江國大輔, 山中玲子, 竹内倫子, 山本龍生
    • Organizer
      第51回日本歯周病学会春季学術大会
    • Place of Presentation
      大宮
    • Year and Date
      2008-04-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Relationship between periodontal condition and plasma reactive oxygen metabolites in patients in the maintenance phase of periodontal treatment2008

    • Author(s)
      Irie K, Tamaki N, Maruyama T, Tomofuji T, Ekuni D, Yamanaka R, Takeuchi T, Yamamoto T
    • Organizer
      第1回岡山医療教育国際シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2008-02-01
    • Related Report
      2009 Final Research Report
  • [Presentation] 予防歯科学の基礎研究の一例2008

    • Author(s)
      友藤孝明
    • Organizer
      第57回日本口腔衛生学会・総会
    • Place of Presentation
      埼玉
    • Related Report
      2009 Final Research Report
  • [Presentation] 歯周炎モデルラットにおける歯肉酸化ストレス度・抗酸化力に対するビタミンC全身投与の効果2008

    • Author(s)
      入江浩一郎, 友藤孝明, 江國大輔, 三部俊博, 東哲司, 丸山貴之, 玉木直文, 山本龍生, 森田学
    • Organizer
      第57回日本口腔衛生学会・総会
    • Place of Presentation
      埼玉
    • Related Report
      2009 Final Research Report
  • [Presentation] Effect of non-surgical periodontal therapy on plasma reactive oxygen metabolites2008

    • Author(s)
      Tamaki N, Yamanaka R, Ekuni dTomofuji T, Yamamoto T, Morita M
    • Organizer
      The 56th Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      Nagoya
    • Related Report
      2009 Final Research Report
  • [Presentation] Effects of Obesity on OxidatiStress in Rat Gingiva2008

    • Author(s)
      Tomofuji T, Sanbe T, Tamaki N, Ekuni D, Kasuyama K, Umakoshi M, Irie K, Azuma T, Murakami J, Kokeguchi S, Yamamoto T, Morita M
    • Organizer
      The 56th Annual Meeting of Japanese Association for DentalResearch
    • Place of Presentation
      Nagoya
    • Related Report
      2009 Final Research Report
  • [Presentation] Effects of Obesity on Oxidative Stress in Rat Gingiva2008

    • Author(s)
      Tomofuji T, Sanbe T, Tamaki N, et.al.
    • Organizer
      The 56th Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      Nagoya
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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