Chewing effect for the stress-related memory defect : An fMRI study

• Project/Area Number: 20791650
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: TACHIBANA Atsumichi Kanagawa Dental College, 生理学分野, 非常勤講師 (80409995)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: fMRI / ストレス / 高次脳機能 / 咀嚼咬合 / 前頭前野 / 歯科心身医学 / 咬合咀嚼 / 認知 / イメージング

Research Abstract

Combining the computerized Kana Pick-out Test as a stressor and fMRI was used for the analysis. This test was examined before and after gum chewing. The result showed the chewing effect for working memory in the brain activity included in the prefrontal cortex. In addition, we investigated the change in brain regional activity for the stress during gum chewing when edentulous subjects switched from mandibular complete dentures (CD) to implant-supported removable overdentures (IOD). This result showed that, within the prefrontal cortex, the neural activity of the frontal pole significantly decreased during gum chewing with IOD when compared to that with CD.

Research Products

• [Journal Article] Effects of chewing in working memory processing (2008)
  • Author(s): Hirano Y, Obata T, Kashikura K, Nonaka H, Tachibana A, Ikehira H, Onozuka M
  • Journal Title: Neuroscience Letter 436 Pages: 189-192
  • Peer Reviewed
• [Journal Article] Chewing ameliorates stress-induced suppression of hippocampal long-term potentiation (2008)
  • Author(s): Ono Y, Kataoka T, Miyake S, Cheng SJ, Tachibana A, Sasaguri KI, Onozuka M
  • Journal Title: Neuroscience 154 Pages: 1352-1359
  • Peer Reviewed
• [Journal Article] Chewing ameliorates stress-induced suppression of hippocampal long-term potentiation (2008)
  • Author(s): Yumie One
  • Journal Title: Neuroscience 154 Pages: 1352-1359
  • Peer Reviewed
• [Journal Article] Effects of chewing in working memory processing (2008)
  • Author(s): Yoshiyuki Hirano
  • Journal Title: Neuroscience Letter 436 Pages: 189-192
  • Peer Reviewed
• [Presentation] fMRIを用いたインプラント治療の脳機能評価 (2009)
  • Author(s): 大野晃教, 小畠隆行, 橘篤導、木本克彦
  • Organizer: 第44回神奈川歯科大学総会
  • Place of Presentation: 神奈川歯科大学, 神奈川
  • Year and Date: 2009-12-05
• [Presentation] Discrimination of self-generated music versus that of other musicians: an fNIRS study (2009)
  • Author(s): A Tachibana, J A Noah, Y Ono, M Onozuka
  • Organizer: Society for Neuroscience
  • Place of Presentation: McCormick Place, Chicago, IL, USA
  • Year and Date: 2009-10-19
• [Presentation] Discrimination of self-generated music versus that of other musicians : an fNIRS study (2009)
  • Author(s): Atsumichi Tachibana
  • Organizer: Society for Neuroscience
  • Place of Presentation: McCormick Place (Chicago, IL, USA)
  • Year and Date: 2009-10-19
• [Presentation] fMRIを用いたインプラント治療効果の評価 (2009)
  • Author(s): 大野晃教, 小畠隆行, 橘篤導、木本克彦
  • Organizer: 第39回日本口腔インプラント学会
  • Place of Presentation: 大阪国際会議場, 大阪
  • Year and Date: 2009-09-26
• [Presentation] Activation of prefrontal cortex with a neuropsychological screening test for mild cognitive impairment: An fMRI approach (2008)
  • Author(s): A Tachibana. Y Hirano, H Nonaka, K Watanabe, I Kanno, M Onozuka, T Obata
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington Convention Center, DC, U.S. A
  • Year and Date: 2008-11-18
• [Presentation] Activation of prefrontal cortex with a neuropsychological screening test for mild cognitive impairment : An fMRI approach (2008)
  • Author(s): Atsumichi Tachibana
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington Convention Center, DC, U.S.A
  • Year and Date: 2008-11-18
• [Presentation] かなひろいテスト時の前頭前野賦活:fMRIによる研究 (2008)
  • Author(s): 橘篤導, 平野好幸、野中博意、小野弓絵、菅野巌、小野塚實、小畠隆行
  • Organizer: 日本磁気共鳴医学会大会
  • Place of Presentation: 旭川市民文化会館, 北海道
  • Year and Date: 2008-09-13
• [Presentation] かなひろいテスト時の前頭前野賦活 : fMRIによる研究 (2008)
  • Author(s): 橘篤導
  • Organizer: 日本磁気共鳴医学会大会
  • Place of Presentation: 旭川市民文化会館
  • Year and Date: 2008-09-13
• [Presentation] Prefrontal activation by attention task (Kana Pick-out Test) (2008)
  • Author(s): 橘篤導, 大塚剛郎、渡邊和子、小畠隆行、池平博夫、小野塚實
  • Organizer: An fMRI study. 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム, 東京
  • Year and Date: 2008-07-09
• [Presentation] Prefrontal activation by attention task (Kana Pick-out Test) ; An fMRI study (2008)
  • Author(s): 橘篤導
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Book] Novel trends in brain science(Interactions between chewing and brain activity in human) (2008)
  • Author(s): Onozuka M, Hirano Y, Tachibana A, Kim W, Ono Y, Sasaguri K, Kubo K, Niwa M, Kanematsu K, Watanabe, K.
  • Publisher: Springer
• [Book] Novel trends in brain science(Involvement of dysfunctional mastication in cognitive system deficits in the mouse) (2008)
  • Author(s): Watanabe K, Kubo K, Nakamura H, Tachibana A, Kim W, Ono Y, Sasaguri K, Onozuka M.
  • Publisher: Springer
• [Remarks]
  • URL: http://www.kdcnet.ac.jp/college/rcbos/index.html
• [Remarks]
  • URL: http://www.imbs-mastication.org/
• [Remarks]
  • URL: http://www.imbs-mastication.org/
• [Remarks]
  • URL: http://www.kdcnet.ac.jp/college/rebos/index.html