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Research of anti-nociceptive effects with sucrose stimulus on pain in human adults

Research Project

Project/Area Number 20791686
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fundamental nursing
Research InstitutionKawasaki University of Medical Welfare

Principal Investigator

KAKEDA Takahiro  Kawasaki University of Medical Welfare, 医療福祉学部, 講師 (60403664)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords看護技術 / 疼痛 / 甘味 / 鎮痛 / 性差 / 蔗糖誘発鎮痛法 / 成人 / 疼痛看護 / 実験的疼痛 / 甘味刺激
Research Abstract

Background : Sucrose-induced analgesia (SIA) has been known as non-pharmacological intervention for pain relief in both rat pups and infants. The mechanism underlying SIA is suggested to be mediated by the central regulating systems such as the endogenous opioids system, taking advantage of sweet taste. This effect is produced by the sweet sensation rather than by the absorption of sucrose. The SIA has been frequently investigated for the pain relief in infants but less so for SIA in adults why the effects are known to decline with growth in rats and infants. The aim of study is to examine whether sucrose stimulus induce the analgesic effects on nociception in adults.
Methods : This study was carried out a randomized control with crossover study. Forty healthy adults participated in this study. Experimental pain was induced using the cold pressor test (CPT), and subjects immersed their hand in cold water. Subjects held a 24% sucrose solution and distilled water as a control in their mouths before and during CPT, respectively. Pain reactivity was measured by six instruments : pain threshold, pain tolerance, biomarker in saliva, psychological ratings with the profile of mood states, each visual analogue scales (VAS) score of pain and taste. Subjects signed a consent form after the purpose and procedures of this study had been explained. This study is approved by the ethical committee at the research institution at Kawasaki University.
Results : The pain threshold increased significantly when male adults held sucrose solution in the mouth relative to distilled water. However, no significant difference in female adults was observed.
Conclusion : These finding suggest the sucrose stimulus could induce the anti-nociceptive effects in male adults. In addition, the gender differences raise the possibility of involvement in expression of sucrose analgesia.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2010 2009

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Potential of sucrose-induced analgesia to relieve pain in male adults: A preliminary study.2010

    • Author(s)
      Kakeda, T.
    • Journal Title

      Japan Journal of Nursing Science (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 成人における蔗糖誘発鎮痛法による痛覚抑制効果と臨床応用に向けた取組み2009

    • Author(s)
      掛田崇寛
    • Organizer
      第29回日本看護科学学会学術集会
    • Place of Presentation
      開催地:千葉県(幕張メッセ)
    • Year and Date
      2009-11-28
    • Related Report
      2009 Final Research Report
  • [Presentation] 成人における蔗糖誘発鎮痛法による痛覚抑制効果と臨床応用に向けた取組み2009

    • Author(s)
      掛田崇寛
    • Organizer
      第29回日本看護科学学会学術集会
    • Place of Presentation
      千葉県(幕張メッセ)
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Beneficial Effects of Sweet Stimuli on Nociception in Adult Humans.2009

    • Author(s)
      Kakeda, T., Ito, M.
    • Organizer
      Sigma Theta Tau International 40th Biennial Convention
    • Place of Presentation
      Indianapolis, USA
    • Year and Date
      2009-11-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Beneficial Effects of Sweet Stimuli on Nociception in Adult Humans2009

    • Author(s)
      Kakeda T., Ito, M.
    • Organizer
      Sigma Theta Tau International 40^<th> Biennial Convention
    • Place of Presentation
      Indianapolis, USA
    • Year and Date
      2009-11-01
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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