Analysis of the neuronal polarity formation mechanism induced by extracellular signals
| Project/Area Number |
20800031
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
TORIYAMA Michinori Nara Institute of Science and Technology, バイオサイエンス研究科, 研究員 (90457151)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | Shootin1 / 神経極性 / Netrin-1 / 軸索 / 軸索ガイダンス / リン酸化 / PAK1 / shootin1 / Shootinl / 軸索ガイダンス分子 |
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| Research Abstract |
Netrin-1 stimulation elevated shootin1 phosphorylation via PAK1. And phosphorylated shootin1 promoted neuronal polarity formation. These results suggest that extracellular molecule Netrin-1 regulates neuronal polarization by promoting shootin1 phosphorylation and activating its activity
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Report
(3 results)
Research Products
(9 results)
